核因子κB信号通路在脓毒症中对多器官功能障碍影响的研究进展

Research progress on the effect of nuclear factor⁃κB signaling pathway on multiple organ dysfunction in sepsis

脓毒症的定义是因机体对感染反应失调所引起的危及生命的器官功能障碍。目前普遍认为病原体的致病性在脓毒症中处于核心地位,但是仅仅靠病原体的致病性并不能完全解释宿主中过度激活的炎症反应及相应的器官功能障碍。越来越多的证据提示相关信号通路失调在脓毒症的发生发展中起着不可替代的作用,而核因子κB(NF-κB)则是调节宿主对感染反应的关键转录因子,并在脓毒症当中协调固有免疫及获得性免疫。本文查阅了近年来的国内外文献,就NF-κB信号传导途径及NF-κB传导通路与器官功能障碍之间的关系进行详细的阐述,以此为临床上脓毒症的诊断及治疗提供新的思路。

Sepsis is defined as a life⁃threatening organ dysfunction caused by a dysregulated body response to infection.At present,it is generally believed that pathogen pathogenicity plays a core status role in sepsis,but pathogen pathogenicity alone cannot fully explain the excessive inflammatory response and corresponding organ dysfunction in the host,and now more and more evidence suggests that the disorder of related signaling pathways plays an irreplaceable role in the occurrence and development of sepsis.Nuclear factor⁃κB(NF⁃κB)is a key transcription factor that regulates the host response to infection and mediates innate and adaptive immunity in sepsis.This article reviews the domestic and foreign literatures in recent years,and elaborates on the NF⁃κB signal transduction pathway and the relationship between NF⁃κB transduction pathway and organ dysfunction,so as to provide new ideas for the diagnosis and treatment of sepsis in clinical practice.