丁酸盐在肠道疾病中作用和机制的研究进展

Research Progress on Role and Mechanism of Butyrate in Intestinal Diseases

丁酸盐是结肠和盲肠部位的微生物群酵解膳食纤维和部分氨基酸的主要产物,可减轻肠道炎症,调节肠道菌群平衡,改善肠黏膜屏障等。近年来国内外诸多研究表明丁酸盐在炎症性肠病、肠易激综合征、肠缺血再灌注损伤、结直肠癌、短肠综合征等肠道疾病中发挥作用。本文就丁酸盐在肠道疾病中作用和机制的研究进展作一综述。

Butyrate is the main product of colonic and cecal microbiota in the fermentation of dietary fiber and some amino acids,which can reduce intestinal inflammation,regulate the balance of intestinal flora,and improve intestinal mucosal barrier.In recent years,a large number of studies at home and abroad have shown that butyrate plays a role in intestinal diseases such as inflammatory bowel disease,irritable bowel syndrome,intestinal ischemia⁃reperfusion injury,colorectal cancer and short bowel syndrome.This article reviewed the research progress on role and mechanism of butyrate in intestinal diseases.