EB病毒与儿童复发性口腔溃疡前口腔病变的关联机制

Mechanism of Association between Epstein-Barr Virus and Oral Lesions before Recurrent Oral Ulcer in Children

目的探究EB病毒与儿童复发性口腔溃疡前口腔病变的关联机制。方法选择90例复发性口腔溃疡前口腔病变的患儿作为本研究的观察组,根据EB病毒DNA是否检出分为检出组(n=66)和未检出组(n=24),同时选择同期的健康儿童50例作为对照组。对比分析观察组和对照组EB病毒DNA检出率、EB病毒DNA检出组与未检出组血清炎症因子水平和免疫功能指标水平。采用Person法分析EB病毒与血清炎症因子和免疫功能指标水平的相关性。结果观察组患儿中EB病毒DNA检出率为73.33%,对照组EB病毒DNA检出率仅为2.00%,差异有统计学意义(P<0.05);检出组患儿血清中TNF-α、CRP、IL-6、IL-8水平以及IgA、IgG和IgM水平均显著高于对照组,差异有统计学意义(P<0.05)。Person相关性分析结果显示,EB病毒DNA检出组与血清炎症因子和免疫功能指标水平之间存在显著的正相关系(P<0.05);而EB病毒DNA未检出组与血清炎症因子和免疫功能指标水平之间的相关性不显著(P>0.05)。结论EB病毒的存在会导致机体血清炎症因子和免疫功能指标水平升高,进而促进复发性口腔溃疡前口腔病变的发生。

Objective To explore the mechanism of association between Epstein-Barr virus and oral lesions before recurrent oral ulcer in children.Methods Ninety children with oral lesions before recurrent oral ulcers were selected as the observation group.According to whether EB virus DNA was detected,they were divided into the detected group(n=66)and the undetected group(n=24),and 50 healthy children at the same time were selected as the control group.The detection rate of EPstein-Barr virus DNA was compared between the observation group and the control group,and the levels of serum inflammatory factors and immune function indexes were compared between the observation group and the control group.The correlation between EB virus and serum inflammatory factors and immune function indexes was analyzed by Person method.Results The detection rate of EPstein-Barr virus DNA in the observation group was 73.33%,and that in the control group was only 2.00%,the difference was statistically significant(P<0.05).The serum levels of TNF-α,CRP,IL-6,IL-8,IgA,IgG and IgM in the detection group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The results of Person correlation analysis showed that there was a significant positive correlation between EB virus DNA detection group and serum inflammatory factors and immune function indexes(P<0.05).There was no significant correlation between EB virus DNA undetected group and serum inflammatory factors and immune function indexes(P>0.05).Conclusion The presence of EPstein-Barr virus can increase the levels of serum inflammatory factors and immune function indexes,and then promote the occurrence of oral lesions before recurrent oral ulcer.