哮喘患儿血清25(OH)D3水平及其与肺功能、呼出FeNO的相关性

Serum 25(OH)D3 Levels in Children with Asthma and their Correlation with Lung Function and Exhaled FeNO

目的探究哮喘患儿血清25(OH)D3水平及其与肺功能、呼出FeNO的相关性。方法择取100例哮喘患儿(2019年4月至2021年4月)为观察组,同时选择同期健康体检者80例为对照组,采用电化学发光法对患儿血清25(OH)D3含量进行检测,检测观察组患儿FeNO指标,同时分析25(OH)D3与FeNO指标与肺功能相关性。结果两组≥50 nmol/L、25-50 nmol/L、<25 nmol/L比较发现,观察组发生率较对照组均升高(P<0.05)。血清25(OH)D3水平与PEF%pred、FEV1%red密切相关,两者呈正比关系,差异对比显著(P<0.05);25(OH)D3水平与FeNO值密切相关,且两者呈负相关,随着25(OH)D3水平不断降低,FeNO值有明显提升,数据差异明显(P<0.05)。结论哮喘患儿主要受到维生素D不足的影响,同时若患儿肺功能出现降低,易导致维生素D不足,可使患儿气道炎症水平增加。

Objective To explore the correlation between serum 25(OH)D3 levels and lung function,exhaled FeNO in children with asthma.Methods 100 children with asthma(April 2019 to April 2021)were selected as the observation group,while 80 healthy individuals in the same period were selected as the control group.The serum 25(OH)D3 content of the children was measured using electrochemiluminescence method,and the FeNO indicators of the observation group were measured.The correlation between 25(OH)D3 and FeNO indicators and lung function was also analyzed.Result Comparing the two groups of≥50 nmol/L,25-50 nmol/L,and<25 nmol/L,it was found that the incidence rate in the observation group was higher than that in the control group(P<0.05).The serum 25(OH)D3 level is closely related to PEF%pred and FEV1%red,and there is a positive correlation between the two,with significant differences(P<0.05);The level of 25(OH)D3 is closely related to the FeNO value,and there is a negative correlation between the two.As the level of 25(OH)D3 continues to decrease,the FeNO value significantly increases,and the data difference is significant(P<0.05).Conclusion Asthmatic children are mainly affected by insufficient vitamin D,and if their lung function decreases,it can easily lead to insufficient vitamin D,which can increase the level of airway inflammation in the children.