伽马刀联合放疗对脑转移瘤患者近期疗效及1年期生存率的影响

Effect of Gamma Knife Combined with Radiotherapy on the Recent Efficacy and 1-year Survival Rate of Patients with Metastatic Tumor of Brain

目的分析伽马刀联合放疗对脑转移瘤患者近期疗效及1年期生存率的影响。方法选取2018年1月—2021年1月徐州医科大学第二附属医院收治的68例脑转移瘤患者作为研究对象,按照随机数字原则分两组,对照组34例,实施常规放疗治疗;观察组34例,实施伽马刀联合放疗。对比两组患者的近期疗效、1年期生存率、神经功能、认知功能与生活质量。结果观察组近期疗效有效率(79.41%)高于对照组(55.88%),差异有统计学意义(χ^(2)=4.300,P<0.05)。观察组1年期生存率(73.53%)高于对照组(44.12%),差异有统计学意义(χ^(2)=6.071,P<0.05)。术前两组患者美国国立卫生研究院卒中量表(NHISS)评分、蒙特利尔认知评估量表(MoCA)评分比较,差异无统计学意义(P>0.05);术后3、6、12个月,观察组NIHSS评分为(15.53±2.63)、(10.51±2.55)、(8.67±1.33)分,均低于对照组的(21.20±2.51)、(15.23±2.72)、(12.47±1.90)分,差异有统计学意义(t=9.094、7.382、7.438,P<0.05);观察组MoCA评分分别为(21.90±2.71)、(22.62±3.50)、(28.41±3.85)分,均高于对照组的(18.22±2.40)、(19.30±3.21)、(23.90±3.42)分,差异有统计学意义(t=5.928、4.076、3.735,P<0.05)。术后12个月对比健康调查表(SF-36)评分,观察组均高于对照组,差异有统计学意义(P<0.05)。结论伽马刀联合放疗治疗脑转移瘤患者,患者近期疗效显著,可改善患者的神经功能与生活质量。

Objective To analyze the effect of gamma knife combined with radiotherapy on the recent efficacy and 1-year survival rate of patients with metastatic tumor of brain.Methods A total of 68 patients with brain metastases who were admitted to the Second Affiliated Hospital of Xuzhou Medical University from January 2018 to January 2021 were selected as the study subjects and divided into two groups according to the principle of random numbers,with 34 patients in the control group implementing conventional radiotherapy treatment;in the observation group,34 patients received gamma knife combined with radiotherapy.Short term outcomes,1-year survival,neurological function,cogni⁃tive function,and quality of life were compared between the two groups.Results In the comparison of recent efficacy,the effective rate of the observation group was 79.41%,which was higher than that of the control group(55.88%),and the difference was statistically significant(χ2=4.300,P<0.05).The 1-year survival rate of the observation group was 73.53%,higher than that of the control group of 44.12%,and the difference was statistically significant(χ2=6.071,P<0.05).There was no significant difference in National Institute of Health Stroke Scale(NHISS)score and Montreal Cog⁃nitive Assessment(MoCA)score between the two groups before surgery(P>0.05).At 3,6,and 12 months after surgery,the NIHSS scores in the observation group were(15.53±2.63)points,(10.51±2.55)points,and(8.67±1.33)points,and the difference was statistically significant(t=9.094,7.382,7.438,P<0.05)the MoCA scores of the observation group were(21.90±2.71)points,(22.62±3.50)points,and(28.41±3.85)points,respectively,which were higher than the con⁃trol group's(18.22±2.40)points,(19.30±3.21)points,and(23.90±3.42)points,and the difference was statistically sig⁃nificant(t=5.928,4.076,3.735,P<0.05).After 12 months of surgery,the MOS Item Short Form Health Survey(SF-36)score was compared and the observation group was higher than the control group,and the difference was statistically significant(P<0.05).Conclusion Gamma knife combined with radiotherapy for the treatment of patients with meta⁃static tumor of brain,patients with significant near and long-term efficacy,can improve the neurological function and quality of life of patients,the application of significant value.