布地奈德福莫特罗联合噻托溴铵吸入剂治疗慢阻肺的疗效及对CRP、SaO_(2)、pH水平影响

Efficacy of Budesonide Formoterol Combined with Tiotropium Bromide Inhalation in the Treatment of Chronic Obstructive Pulmonary Disease and its Effect on CRP,SaO_(2)and pH Levels

目的探究布地奈德福莫特罗(BD/FM)联合噻托溴铵(TB)吸入剂治疗慢阻肺(COPD)的临床疗效及对患者C反应蛋白(CRP)、血氧饱和度(SaO_(2))、pH水平的影响。方法选取2019年3月-2022年3月佳木斯市中心医院收治的80例COPD患者,采用随机数字表法分为对照组(40例)和观察组(40例)。对照组给予BD/FM吸入治疗,观察组应用BD/FM联合TB吸入剂治疗,比较两组临床疗效、血气分析指标[血氧饱和度(SaO_(2))、动脉血二氧化碳分压(PaCO_(2))、pH值]、肺通气功能[用力肺活量(FVC)、1 s用力呼气容积(FEV_(1))、1 s率(FEV_(1)/FVC)]、生化指标[C反应蛋白(CRP)、白细胞介素-6(IL-6)]、不良反应。结果观察组治疗有效率高于对照组(P<0.05);观察组治疗后SaO_(2)、pH值高于对照组,PaCO_(2)低于对照组(P<0.05);观察组治疗后FVC、FEV_(1)、FEV_(1)/FVC高于对照组,CRP、IL-6低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论BD/FM联合TB吸入治疗COPD疗效肯定,可有效改善患者血氧状态及肺通气功能,提高SaO_(2)、PH指标,下调CRP等炎性表达,且不增加不良反应。

Objective To investigate the clinical efficacy of budesonide formoterol(BD/FM)combined with tiotropium bromide(TB)inhalation in the treatment of chronic obstructive pulmonary disease(COPD)and its effect on C-reactive protein(CRP),oxygen saturation(SaO_(2))and pH level.Methods A total of 80 patients with COPD admitted to Jiamusi Central Hospital from March 2019 to March 2022 were selected and divided into control group(40 patients)and observation group(40 patients)by random number table method.The control group was treated with BD/FM inhalation,and the observation group was treated with BD/FM combined with TB inhalation.The clinical efficacy,blood gas analysis indexes[oxygen saturation(SaO_(2)),arterial carbon dioxide partial pressure(PaCO_(2)),pH value],pulmonary ventilation function[forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1)),forced vital capacity rate of one second(FEV_(1)/FVC)],biochemical indexes[C-reactive protein(CRP),interleukin-6(IL-6)]and adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,SaO_(2)and pH in the observation group were higher than those in the control group,and PaCO_(2)was lower than that in the control group(P<0.05).FVC,FEV_(1)and FEV_(1)/FVC in the observation group were higher than those in the control group,and CRP and IL-6 were lower than those in the control group after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion BD/FM combined with TB inhalation is effective in the treatment of COPD,which can effectively improve the blood oxygen status and pulmonary ventilation function of patients,improve the indexes of SaO_(2)and PH,and down-regulate the inflammatory expression of CRP without increasing adverse reactions.