生长因子和细胞因子在创面修复过程中作用的研究进展

Research advances on growth factors and cytokines in wound repair

创面修复是个复杂的,由多种细胞参与,通过细胞的迁移、增殖、分化,实现组织和上皮再生的过程。这些复杂的生理生化反应都受到细胞信号转导调控,参与创面修复的细胞会分泌生长因子或细胞因子,这些因子再参与到调控创面愈合的信号通路中,促进创面愈合。生长因子应用于创面治疗仍是热点研究,本文就生长因子和细胞因子在创面修复过程中的研究综述。

Wound repair is a complex process involving a variety of cells,which achieve tissue and epithelial regeneration via cell migration,proliferation and differentiation.These complex physiological and biochemical reactions are regulated by cell signal transduction.Cells involved in wound repair will secrete some growth factors or cytokines,and these factors will participate in the signal pathway regulating wound healing to promote wound healing.The application of growth factors in wound treatment is still a hot topic.This article reviews the research of growth factors and cytokines in the process of wound repair.