间充质干细胞治疗吸入性损伤的动物实验研究进展

Advances in animal experiment studies on mesenchymal stem cells for the treatment of inhalation injury

吸入性损伤是由热力及吸入化学物质引起的呼吸道和肺实质的损伤,作为烧伤三大主要死亡原因之一,病死率较高,临床上尚无特异有效的治疗方法。间充质干细胞具有归巢、促进增殖、抗细胞凋亡、自分泌与旁分泌、抗炎与免疫调节等作用。文章主要综述了不同组织来源的间充质干细胞治疗吸入性损伤的动物实验研究,表明间充质干细胞可以通过多种途径减轻吸入性损伤,提高治疗效果,改善疾病预后,是具有较好临床应用前景的治疗选择。

Inhalation injury is one of the three major causes of death in burns,which damages the respiratory tract or pulmonary parenchyma by heat or chemical irritants carried into the airways during respiration.The mortality of inhalation injury is high,however there is no specific and effective methods of clinical treatment.Mesenchymal stem cells have the functions of homing,promoting proliferation,anti-apoptosis,autocrine and paracrine,anti-inflammatory and immunomodulatory effects.This article reviews a large number of animal experimental studies on the treatment of inhalation injury with mesenchymal stem cells from different sources,which shows that mesenchymal stem cells can attenuate inhalation injury and improve the effectiveness of treatments and the prognosis of disease in various ways.Thus,the cell therapy with mesenchymal stem cells is an available option with promising prospects of clinical application.