首发和复发抑郁症患者血清炎症因子水平差异分析

Difference of serum inflammatory factor levels between patients with firstepisodeand recurrent depression

目的:探究首发抑郁症患者和复发抑郁症患者之间血清炎症因子浓度的差异。方法:选取医院收治的95例抑郁症患者分为首发组、复发组,并招募45例健康者为对照组。通过酶联免疫吸附法、化学发光法、酶循环法和免疫分散比浊法测定所有样品中的MT、IL-6、Hcy、C3和C4水平。结果:首发组和复发组患者的各项结果都明显高于对照组。首发组和复发组患者的血清MT、IL-6和HCy含量均显著高出对照组,而首发组患者的血清C3水平明显低于复发组。抑郁症患者的血清MT水平显著上升。结论:复发性抑郁症患者的血清炎症因子浓度明显升高。

Objective:To investigate the differences in serum inflammatory factor concentrations between patients with first-episode depression and patients with relapsed depression.Methods:A total of 95 depressed patients were included in this study and were divided into a first-episode group,a relapse group,and a healthy control group.MT,IL-6,Hcy,C3,and C4 levels were measured in all samples by enzyme-linked immunosorbent assay,chemiluminescence,enzyme cycling,and immunodispersive turbidimetric assay.Results:All levels in the first and relapse groups were significantly higher than that in the control group.Conclusions:Serum inflammatory factor concentrations were significantly higher in patients with recurrent depression.