溴结构域蛋白4在糖尿病及其并发症中的作用研究进展

Review of BRD4 in diabetes and its complications

糖尿病是一组由多病因引起的以慢性高血糖为特征的代谢性疾病,是由于胰岛素分泌不足和(或)利用缺陷所引起的。体内长期碳水化合物、脂肪、蛋白质代谢紊乱,可引起多系统损害,导致眼、肾、神经、心脏、血管等组织器官出现慢性进行性病变、功能减退及衰竭。研究发现,溴结构域蛋白4(Bromodomain-containing protein 4,BRD4)在糖尿病及其并发症中发挥重要作用,它可识别并结合于靶基因的启动子区域,促进目的基因表达,从而调控糖尿病及其并发症的发生发展。因此,靶向抑制BRD4的表达,可能为治疗糖尿病提供了一种新的治疗途径。本文对BRD4在糖尿病及其并发症中的作用进行总结,强调针对BRD4的表观遗传学治疗策略在糖尿病及其并发症治疗中的潜力。

Diabetes is a group of metabolic diseases characterized by chronic hyperglycemia caused by multiple etiologies.It is caused by insufficient insulin secretion and/or deficiency in insulin utilization.The long-term disorder of carbohydrate,fat,and protein metabolism in the body can cause multiple system damage,leading to chronic progressive disease,functional decline,and failure of tissues and organs such as eyes,kidneys,nerves,heart,and blood vessels.At present,more and more studies have found that bromodomain protein 4 plays an important role in diabetes and its complications.It can recognize and bind to the promoter region of the target gene,promote the expression of the target gene,and thus regulate the occurrence and development of diabetes and its complications.Therefore,targeted inhibition of BRD4 expression may provide a new therapeutic approach for the treatment of diabetes.This review summarizes the role of BRD4 in diabetes and its complications and highlight the potential of epigenetic treatment strategies targeting BRD4 in the treatment of diabetes complications.