光相干断层扫描血管成像在中心性浆液性脉络膜视网膜病变量化研究中的应用

Advances in application of optical coherence tomography angiography for quantitative analysis in central serous chorioretinopathy

中心性浆液性脉络膜视网膜病变(CSC)是具有代表性的肥厚型脉络膜谱系疾病之一。眼底血管造影检查尽管可以作为CSC的诊断金标准,但是为有创检查,临床应用具有一定风险,同时无法获取定量参数。光相干断层扫描血管成像(OCTA)作为无创、可量化的检查,是研究CSC发病机制和诊断治疗的重要影像学手段。随着技术的不断改进,扫频源OCTA具备了更可观的扫描深度、更广的扫描范围和更高的分辨率。OCTA的发展深化了对CSC发病特点与机制的研究,促进了对CSC病理生理学的理解,从而为临床诊疗提供了新思路。基于OCTA,CSC的脉络膜及视网膜均显示了血管系统的定性及定量改变。OCTA引导的CSC治疗和基于OCTA的预后标志物的发现挑战了传统的造影技术在CSC中的应用。随着OCTA技术的不断完善和进步,传统造影联合OCTA将为CSC的诊治带来巨大益处。

Central serous chorioretinopathy(CSC)is one of the representative pachychoroid spectrum disease.Although fundus fluorescein angiography and indocyanine green angiography can be used as the gold standard for the diagnosis of CSC,they are invasive examinations,which may bring certain risks in clinical application and cannot help us obtain quantitative parameters.Optical coherence tomography angiography(OCTA),as a non-invasive and quantitative examination,is an important imaging tool for understanding the pathogenesis,diagnosis and treatment of CSC.With the advancement of OCTA,the swept-source OCTA has a satisfying scanning depth,a wider scanning range and a higher resolution.The development of OCTA broadens the horizons of the pathogenesis of CSC,promotes the understanding of the pathophysiology of CSC,and sheds new light for its clinical diagnosis and treatment.Based on OCTA,the choroid and retina in eyes with CSC are presented with qualitative and quantitative changes in vascular system.OCTA-guided CSC treatment and the discovery of prognostic markers based on OCTA challenge the application of traditional imaging techniques in CSC.With the continuous improvement and progress of OCTA technology,traditional angiography combined with OCTA will bring great benefits to the diagnosis and treatment of CSC.This review summarizes the quantitative application of OCTA in the pathogenesis,diagnosis and treatment of CSC.