淫羊藿苷防治膝骨性关节炎作用机制的研究进展

Research progress on mechanism of icariin in prevention and treatment of knee osteoarthritis

膝骨性关节炎(knee osteoarthritis,KOA)是临床中最常见的慢性退行性骨关节疾病,其主要的病理特征是关节软骨的退变、软骨下骨小梁骨重塑失调和滑膜病变,严重影响患者的生活质量,对家庭和社会造成巨大的经济负担。中药在防治KOA方面具有一定的优势,其中,淫羊藿中有效成分淫羊藿苷对防治KOA具有一定作用。通过对淫羊藿苷从抗炎、保护软骨细胞、抑制细胞凋亡、抑制破骨细胞方面防治KOA作用机制的研究进展进行综述,为进一步研究淫羊藿苷防治KOA提供理论依据。

Knee osteoarthritis(KOA) is the most common chronic degenerative disease of bone and joint in clinic.Its main pathological features are articular cartilage degeneration,subchondral trabecular bone remodeling disorder and synovial lesions,which seriously affect the quality of life of patients and cause huge economic burden to families and society.Traditional Chinese medicine has certain advantages in the prevention and treatment of KOA,among which icariin,the effective component of Epimedii Folium,has certain effect on the prevention and treatment of KOA.This article reviews the research progress of icariin on anti-inflammatory,chondrocyte protection,inhibition of apoptosis,inhibition of osteoclasts in the prevention and treatment of KOA,in order to provide a theoretical basis for further study of icariin prevention and treatment of KOA.