摘要
天舒胶囊是由古代经典名方“大川芎方”改进研制而成的中药复方,由川芎、天麻2味药物组成,现代药理学研究表明该药具有镇痛、镇静、降压、抗炎、抑制血小板聚集及血栓形成等药理作用。临床上主要用于治疗偏头痛、血管神经性头痛、脑梗死、紧张型头痛、高血压血瘀证等疾病。对天舒胶囊的化学成分、药理作用及临床应用方面的研究进展加以总结,并结合中药质量标志物(quality marker,Q-Marker)中“五原则”的概念对天舒胶囊的潜在Q-Marker进行预测分析,提示天麻素、天麻苷元、巴利森苷B、阿魏酸、藁本内酯、洋川芎内酯I、洋川芎内酯H和川芎嗪可作为天舒胶囊的Q-Marker,可选择其作为质控指标,为天舒胶囊的质量控制与后续研究提供参考。
Tianshu Capsules(天舒胶囊)is a traditional Chinese medicine compound preparation developed from the ancient classic recipe“Dachuanxiong Fang(大川芎方)”,which is composed of Chuanxiong(Chuanxiong Rhizoma)and Tianma(Gastrodiae Rhizoma).Modern pharmacological researches indicated that it has various pharmacological effects,such as analgesia,sedation,lower blood pressure,anti-inflammatory,as well as inhibition of platelet aggregation and thrombus formation.In clinic,Tianshu Capsules is often used for the treatment of migraine,angioneurotic headache,cerebral infarction,tension-type headache,hypertension,blood stasis and other diseases.Based on the review of the chemical constituents,pharmacological effects,and clinical applications of Tianshu Capsules,its quality markers(Q-Markers)were predicted and analyzed according to the“five principles”of Q-Markers in traditional Chinese medicine.The results suggested that gastrodin,4-hydroxybenzyl alcohol,parishin B,ferulic acid,ligustilide,senkyunolides I,senkyunolides H,and tetramethylpyrazine could be used as Q-Markers of Tianshu Capsules,which can provide reference for its quality control and other research in the future.
作者
顾潇
李臻阳
商娟
李雪娇
袭晓昀
王宇
王永生
邹建东
许美娟
GU Xiao;LI Zhen-yang;SHANG Juan;LI Xue-jiao;XI Xiao-yun;WANG Yu;WANG Yong-sheng;ZOU Jian-dong;XU Mei-juan(Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing 210029,China;Nanjing University of Chinese Medicine,Nanjing 210023,China)
出处
《中草药》
CAS
CSCD
北大核心
2023年第8期2686-2697,共12页
Chinese Traditional and Herbal Drugs
基金
国家科技重大专项“重大新药创制”(2012ZX09303-009-002)
江苏省自然科学基金面上项目(BK20181504)
江苏省高层次卫生人才“六个一工程”拔尖人才项目(LGY2019072)。