碘营养状况对甲状腺癌生物标志物影响的研究进展

Research progress on the influence of iodine nutritional status on biomarkers of thyroid cancer

甲状腺癌是内分泌系统常见的恶性肿瘤之一,发病率呈逐年上升趋势。目前,甲状腺癌的主要诊断方法为超声和甲状腺穿刺细胞学检查,但由于灵敏度和/或特异度偏低,越发难以满足当前临床诊断的需求。甲状腺癌生物标志物的发现为该病的诊断、发病机制及预后研究提供了重要线索。碘作为人体必需的微量元素之一,与甲状腺关系十分密切。明确碘营养状况与甲状腺癌生物标志物的关系,对甲状腺癌的诊断、发病机制及预后研究等方面均有重要的现实意义。本文基于系统生物学研究,从基因、转录、蛋白、代谢4个方面分析碘营养状况对甲状腺癌生物标志物的影响。

Thyroid cancer is one of the common malignant tumors in the endocrine system,and its incidence is increasing year by year.At present,the main diagnostic methods for thyroid cancer are ultrasound and thyroid puncture cytology.However,due to low sensitivity and/or specificity,it is increasingly difficult to meet the current clinical diagnostic needs.The discovery of biomarkers in thyroid cancer provides important clues for the diagnosis,pathogenesis and prognosis of the disease.As one of the essential trace elements in human body,iodine is closely related to the thyroid gland.Clarifying the relationship between iodine nutritional status and biomarkers of thyroid cancer has important practical significance for the diagnosis,pathogenesis and prognosis of thyroid cancer.Based on the research of systems biology,this article analyzes the influence of iodine nutritional status on biomarkers of thyroid cancer from four aspects of gene,transcription,protein and metabolism,