表没食子儿茶素没食子酸酯纳米化研究进展

Advances in epigallocatechin gallate nanotechnology

表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)是茶叶中的主要活性成分,具有抗炎、抗氧化等诸多生物活性。然而,体内、体外实验结果与流行病学研究存在较大差异,主要原因是EGCG不稳定、生物利用度低。EGCG口服后只有极少数能被肠道所吸收,难以发挥其药理特性。随着科技的发展,科学家们发现纳米化技术能够提高EGCG稳定性,改善EGCG生物利用度。还能够在纳米颗粒上添加靶向分子,使其能定向输送到特定部位,提高EGCG药理特性。纳米化EGCG在食品、医药领域具有广阔前景。碳水化合物、脂质和蛋白质等经过纳米化处理后可以作为包裹EGCG的材料。但是目前关于纳米化EGCG的研究主要集中在体内体外的实验,缺少临床数据支撑,还需要对其安全性和药代动力学等进一步补充和深入研究。因此,本文综述了EGCG吸收、代谢及纳米化EGCG研究进展,以期为EGCG进一步的开发利用提供借鉴。

Epigallocatechin gallate(EGCG)is the main active ingredients in tea,which has many biological activities,such as anti-inflammation,anti-oxidation and so on.However,there are significant differences between the in vivo and in vitro results and the epidemiological studies,mainly due to the instability and low bioavailability of EGCG.Only a few of EGCG can be absorbed by the intestine after oral administration,which makes it difficult to exert its pharmacological properties.Many defects of EGCG have seriously hindered the development of pharmaceutical and dietary products related to EGCG.With the development of science and technology,scientists have found that nanotechnology can improve the stability of EGCG and improve the bioavailability of EGCG.In addition,targeting molecules can be added to the nanoparticles so that they can be delivered to specific sites and improve the pharmacological properties of EGCG.Nano-EGCG has broad prospects in the field of food and medicine.After nanocrystallization,carbohydrates,lipids and proteins can be used as EGCG-coated materials.However,at present,the research on nanocrystalline EGCG is mainly focused on in vivo and in vitro experiments,and lack of clinical data to support.Further studies are needed on its safety and pharmacokinetics.Therefore,this paper reviewed the research progress of EGCG absorption,metabolism and nanocrystalline EGCG,in order to provide references for the further development and utilization of EGCG.