司库奇尤单抗治疗银屑病合并慢性乙型肝炎2例

Psoriasis with Chronic Hepatitis B Treated with Secukinumab:Two Cases Report

例1男,20岁,头皮红色斑块伴鳞屑4年,加重累及耳部与躯干2年,诊断为中度斑块型银屑病、慢性乙型肝炎病毒(hepatitis B virus, HBV)携带状态;例2女,30岁,全身弥漫性红斑、丘疹伴厚层鳞屑反复发作15年,诊断为重度斑块型银屑病、HBeAg阴性慢性乙型肝炎(chronic hepatitis B,CHB)。2例患者经预防性抗病毒治疗达到非活动性HBV感染期后,继续抗病毒同时用司库奇尤单抗(secukinumab)治疗银屑病,2例患者银屑病均得到有效缓解,且乙肝未活化。

Case 1 was a 20-year-old male,who had red plaques with scales on the scalp for 4 years and involvement of the ears and trunk for 2 years,he was diagnosed with moderate plaque psoriasis and chronic hepatitis B virus(HBV)carrying state.Case 2 was a 30-year-old female,who had recurrent generalized diffuse erythema,papules and thick scales for 15 years,she was diagnosed with severe plaque psoriasis and HBeAg-negative chronic hepatitis B(CHB).After the two patients reached the inactive HBV infection stage by preventive antiviral therapy,they continued antiviral therapy and treated psoriasis with secukinumab.Both patients had effective remission of psoriasis,and hepatitis B was not activated.