阿托伐他汀对冠状动脉瘤样扩张患者的治疗效果观察

Therapeutic Effect Observation of Atorvastatin in Patients with Coronary Artery Aneurysmal Dilation

目的:分析冠状动脉瘤样扩张患者应用阿托伐他汀的治疗效果。方法:选取2020年3月—2021年6月甘肃省第二人民医院收治的78例冠状动脉瘤样扩张患者为研究对象,根据随机数字表法分为观察组与对照组,各39例。对照组采用常规治疗,观察组在对照组基础上加用阿托伐他汀治疗。比较两组心绞痛疗效、血脂及血清C反应蛋白(CRP)水平。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.013)。治疗前,两组总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05);治疗后,观察组TC、TG、LDL-C水平低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清CRP水平比较,差异无统计学意义(P>0.05);治疗后,两组血清CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:冠状动脉瘤样扩张患者应用阿托伐他汀进行治疗,可有效改善心绞痛发作情况,调节血脂水平,降低血清CRP水平。

Objective:To analyze the therapeutic effect of atorvastatin in patients with coronary artery aneurysmal dilation.Methods:A total of 78 patients with coronary artery aneurysmal dilation admitted to the Second People's Hospital of Gansu Province from March 2020 to June 2021 were selected as the study subjects.They were randomly divided into an observation group and a control group,with 39 patients in each group,using a random number table method.The control group received routine treatment,while the observation group received atorvastatin treatment on the basis of control group.The efficacy of angina pectoris,blood lipids,and serum C-reactive protein(CRP)levels were compared between two groups.Results:The total effective rate in the observation group was higher than that in the control group,with a statistically significant difference(P=0.013).Before treatment,there was no statistically significant difference in the levels of total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)between the two groups(P>0.05);After treatment,the levels of TC,TG,and LDL-C in the observation group were lower than those in the control group,while the levels of HDL-C in the observation group were higher than those in the control group,with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in serum CRP levels between the two groups(P>0.05);After treatment,serum CRP levels in two groups were lower than those before treatment,and the observation group was lower than the control group,with a statistically significant difference(P<0.05).Conclusion:The application of atorvastatin in the treatment of patients with coronary artery aneurysmal dilation can effectively improve the onset of angina pectoris,regulate blood lipid levels,and lower serum CRP levels.