多索茶碱联合噻托溴铵吸入剂治疗慢性阻塞性肺疾病的临床效果分析

Clinical Effect Analysis of Doxofylline Combined with Tiotropium Bromide for Inhalation in Treatment of Chronic Obstructive Pulmonary Disease

目的:探讨慢性阻塞性肺疾病采用多索茶碱联合噻托溴铵吸入剂治疗的临床效果。方法:选取2020年5月—2021年4月南通市海门区海门港新区中心卫生院收治的76例慢性阻塞性肺疾病患者作为研究对象,根据随机数字表法分为常规组和试验组,各38例。常规组采用多索茶碱治疗,试验组在常规组基础上联合噻托溴铵吸入剂治疗。对比两组肺功能、证候积分、满意度、复发情况及不良反应发生情况。结果:治疗前,两组用力肺活量、呼气流量峰值、每分钟最大通气量比较,差异无统计学意义(P>0.05);治疗后,两组用力肺活量、呼气流量峰值、每分钟最大通气量均高于治疗前,且试验组高于常规组,差异有统计学意义(P<0.05)。治疗前,两组喘息、呼吸困难、咳嗽证候积分比较,差异无统计学意义(P>0.05);治疗后,两组喘息、呼吸困难、咳嗽证候积分均低于治疗前,且试验组低于常规组,差异有统计学意义(P<0.05)。试验组满意度高于常规组,差异有统计学意义(P=0.022 4)。试验组复发率低于常规组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:多索茶碱、噻托溴铵吸入剂联合使用,对慢性阻塞性肺疾病患者的治疗效果明显,可有效缓解症状,控制复发情况,提高满意度。

Objective:To investigate the clinical effect of doxofylline combined with tiotropium bromide for inhalation in the treatment of chronic obstructive pulmonary disease.Methods:From May 2020 to April 2021,a total of 76 patients with chronic obstructive pulmonary disease admitted to Central Health Center of Haimen Port New Area of Haimen District of Nantong were selected as the study subjects.They were divided into conventional group and test group according to random number table method,with 38 cases in each group.The conventional group was treated with doxofylline and the test group was treated with tiotropium bromide for inhalation on the basis of conventional group.The lung function,syndrome scores,satisfaction,recurrence and occurrence of adverse reactions in two groups were compared.Results:Before treatment,there were no significant differences in forced vital capacity,peak expiratory flow and maximum voluntary ventilation per minute between the two groups(P>0.05).After treatment,the forced vital capacity,peak expiratory flow,and maximum voluntary ventilation per minute in the two groups were higher than those before treatment,and the test group was higher than the conventional group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the syndrome scores of wheezing,dyspnea and cough between the two groups(P>0.05).After treatment,the syndrome scores of wheezing,dyspnea,and cough in the two groups were lower than those before treatment,and the test group was lower than the conventional group,and the difference was statistically significant(P<0.05).The satisfaction in the test group was higher than that in the conventional group,and the difference was statistically significant(P=0.0224).The recurrence rate in the test group was lower than that in the conventional group,and the difference was statistically significant(P<0.05).There were no significant differences in total incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of doxofylline with tiotropium bromide for inhalation has significant effect in the treatment of patients with chronic obstructive pulmonary disease.it can effectively relieve the symptoms,control the recurrence and improve the satisfaction.