胃癌患者CA125、CEA及G-17与临床病理特征的相关性分析

Correlation Analysis of CA125,CEA,G-17 and Clinicopathological Characteristics of Gastric Cancer Patients

目的 探讨胃癌患者糖链抗原125(CA125)、癌胚抗原(CEA)、胃泌素-17(G-17)与临床病理特征的相关性。方法 选择2019年6月-2021年6月我院收治的112例胃癌患者作为研究对象,将所有患者的临床资料作为胃癌组,并选取同期体检健康者112例的临床资料作为健康组。比较胃癌组与健康组血清CA125、CEA及G-17水平,胃癌患者血清CA125、CEA及G-17与临床病理特征的相关性。结果 胃癌组血清CA125、CEA及G-17水平高于健康组,差异有统计学意义(P<0.05);在胃癌患者中病理Ⅲ、Ⅳ期、淋巴结转移、低分化的血清CA125、CEA及G-17阳性率高于阴性率(P<0.05),同时血清CA125阳性率分别与病理分期、淋巴结转移、分化程度成正相关(r=0.475,0.468,0.452,P<0.05);血清CEA阳性率分别与病理分期、淋巴结转移、分化程度成正相关(r=0.425,0.453,0.427,P<0.05);血清G-17阳性率分别与病理分期、淋巴结转移、分化程度成正相关(r=0.439,0.421,0.438,P<0.05)。结论 胃癌患者的血清CA125、CEA及G-17水平较高,且血清CA125、CEA及G-17阳性率与病理分期、淋巴结转移、分化程度均呈正相关,可为预后情况提供参考价值。

Objective To investigate correlation between clinical and pathological characteristics of carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),and gastrin 17(G-17)of gastric cancer patients.Methods The paper chose 112 patients with gastric cancer admitted to our hospital from June 2019 to June 2021 as study objects,clinical data of patients were included in gastric cancer group,and clinical data of 112 healthy individuals with physical examination during the same period in health group.Levels of serum CA125,CEA,and G-17 between gastric cancer group and healthy group,correlation between serum CA125,CEA,and G-17 and clinical pathological characteristics of gastric cancer patients were compared.Results Levels of serum CA125,CEA,and G-17 in gastric cancer group were significantly higher than healthy group(P<0.05).Positive rates of serum CA125,CEA,and G-17 were higher than negative rates of gastric cancer patients,(P<0.05).Positive rate of serum CEA was positively correlated with pathological stage,lymph node metastasis,and degree of differentiation respectively(r=0.425,0.453,0.427,P<0.05).Positive rate of serum G-17 was positively correlated with pathological stage,lymph node metastasis,and degree of differentiation(r=0.439,0.421,0.438,P<0.05).Conclusion Levels of serum CA125,CEA,and G-17 of gastric cancer patients are relatively high,positive rates of serum CA125,CEA,and G-17 are positively correlated with pathological stage,lymph node metastasis,and differentiation,which can provide reference value for prognosis.