达格列净联合胰岛素治疗2型糖尿病效果及对肾功能的影响

Effect of Daggligin Combined with Insulin on Type 2 Diabetes and Its Influence on Renal Function

目的 研究采用达格列净联合胰岛素治疗2型糖尿病的效果及对肾功能的影响。方法 选择2019年1月-2021年9月阜宁县人民医院收治的2型糖尿病患者80例,依据数字随机表法分为对照组和治疗组,每组各40例。对照组予以胰岛素治疗,治疗组采用达格列净联合胰岛素治疗。分析两组临床治疗效果、治疗前后肾功能指标、血糖水平以及不良反应发生率。结果 治疗后,治疗组治疗有效率高于对照组(P<0.05)。治疗前,两组患者肾功能指标比较不显著(P>0.05);治疗后,治疗组血尿素氮、血肌酐、UACR指数均低于对照组,且治疗组eGFR指数高于对照组(P<0.05)。治疗前,两组患者血糖水平比较不显著(P>0.05);治疗后,治疗组FPG、2hPG、HbA1指数均低于对照组(P<0.05)。治疗后,治疗组出现不良反应发生率低于对照组(P<0.05)。结论 达格列净联合胰岛素来改善2型糖尿病患者的血糖水平与肾功能各项指标效果显著,可消除不良反应,有助于改善临床病症,值得借鉴与应用。

Objective To discuss effect of daggligin combined with insulin on type 2 diabetes and its influence on renal function.Methods The paper chose 80 patients with type 2 diabetes admitted to Funing County People's Hospital from January 2019 to September 2021,and divided them into control group and treatment group according to digital random table method,with 40 cases in each group.Control group was treated with insulin,while treatment group with daggliflozin combined with insulin.Clinical treatment effect,renal function indicators,blood glucose levels,and adverse reactions incidence before and after treatment were analyzed between two groups.Results After treatment,effective rate of treatment in treatment group was,higher than control group(P<0.05).Before treatment,there was no significant difference in renal function indicators between two groups(P>0.05).After treatment,the blood urea nitrogen,blood creatinine,and UACR index in treatment group was lower than control group,and the eGFR index in treatment group was higher than control group(P<0.05).Before treatment,there was no significant difference in blood glucose levels between two groups(P>0.05).After treatment,the FPG,2hPG,and HbA1 indexes in treatment group were lower than control group(P<0.05).After treatment,adverse reactions incidence in treatment group was,lower than control group(P<0.05).Conclusion Study showed,dagelin combined with insulin can achieve significant effect for blood sugar level and renal function indicators of type 2 diabetes patients,can eliminate adverse reactions,improve clinical symptoms,which is worthy of reference and application.