氨氯地平联合二甲双胍对肥胖型高血压的治疗效果分析

Curative Effect Analysis of Amlodipine Combined with Metformin for Obese Hypertension

目的 浅析在肥胖型高血压患者治疗中氨氯地平联合二甲双胍的治疗效果。方法 以2020年1月-2021年6月本中心收治的80例肥胖型高血压患者为研究对象,随机分两组,对照组、观察组,每组各40例,前组采用氨氯地平治疗,后组联合二甲双胍治疗,分析组间治疗效果。结果 治疗前两组患者血脂指标水平差异甚微,组间无统计学意义(P>0.05);治疗后观察组患者血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平较低,高密度脂蛋白胆固醇(HDL-C)水平较高(P<0.05)。组间血压水平比较:治疗前两组患者血压水平、体质量指数以及腰臀比差异甚微(P>0.05),治疗后观察组患者血压水平以及各指标较低(P<0.05)。观察组患者治疗有效率较高(P<0.05)。结论 在肥胖型高血压患者治疗中,以氨氯地平为基础,联合二甲双胍治疗效果理想,值得研究。

Objective To analyze effect of amlodipine combined with metformin in treatment of obese hypertensive patients.Methods The paper chose 80 patients with obese hypertension admitted to our center from January 2020 to June 2021,and divided them into two groups randomly,40 cases in control group and observation group each.The former group was treated with amlodipine,and the latter group with metformin.Curative effect between the groups was analyzed.Results Before treatment,there was little difference between two groups in level of blood lipid indicators,there was no significant difference between the groups(P>0.05).After treatment,levels of serum total cholesterol(TC),triglycerides(TG),and low density lipoprotein cholesterol(LDL-C)in observation group were lower,while levels of high density lipoprotein cholesterol(HDL-C)were higher(P<0.05).Comparison of blood pressure levels between groups:there was little difference in blood pressure levels,body mass index,and waist to hip ratio between two groups before treatment(P>0.05),while blood pressure levels and various indicators in observation group were lower after treatment(P<0.05).Effective rate of treatment in observation group was higher(P<0.05).Conclusion Amlodipine combined with metformin can achieve ideal effect in treatment of obese hypertensive patients,which is worthy of research.