多囊卵巢综合征患者颈动脉内膜中层厚度与心血管疾病危险因素关系的研究

Relationship between carotid intima-media thickness and cardiovascular disease risk factors in patients with polycystic ovary syndrome

目的探讨多囊卵巢综合征(PCOS)患者颈动脉内膜中层厚度(CIMT)与心血管疾病危险因素的关系。方法选取100例PCOS患者为PCOS组,110例正常女性为对照组,测量两组体重、血压、静息心率、血糖、血脂、CIMT,再行糖耐量及胰岛素释放试验。比较两组临床指标水平,多因素线性回归分析PCOS患者CIMT与心血管疾病之间的相关危险因素。结果PCOS组CIMT为(0.65±0.08)mm,相比对照组的(0.51±0.06)mm显著升高(P<0.05);相比对照组,PCOS组的体质量指数,收缩压,舒张压,静息心率,空腹血糖及胰岛素,餐后1、2 h血糖及胰岛素,甘油三酯,高密度脂蛋白水平比较差异有统计学意义(P<0.05)。结论PCOS患者CIMT增厚与静息心率增快及高密度脂蛋白降低密切相关,且静息心率增快、高密度脂蛋白降低等增加心血管疾病相关风险因素,PCOS患者相比正常女性CIMT显著增厚。

Objective To investigate the relationship between carotid intima-media thickness(CIMT)and cardiovascular disease risk factors in patients with polycystic ovary syndrome(PCOS).Methods A total of 100 PCOS patients were selected as PCOS group and 110 normal females were selected as control group.Weight,blood pressure,resting heart rate,blood glucose,blood lipid,CIMT,glucose tolerance and insulin release tests were measured in both groups.The levels of clinical indicators in the two groups were compared,and the correlation between CIMT and cardiovascular disease risk factors in PCOS patients was analyzed by multivariate linear regression.Results The CIMT ofPCOS group was(0.65±0.08)mm,which was significantly higher than that of control group(0.51±0.06)mm(P<0.05).Compared with the control group,there were statistically significant differences in body mass index,systolic blood pressure,diastolic blood pressure,resting heart rate,fasting blood glucose and insulin,blood glucose and insulin,triglyceride and high density lipoprotein levels 1 and 2 h after meals in PCOS group(P<0.05).Conclusion The thickening ofCIMT in PCOS patients is closely related to the increase ofresting heart rate and the decrease of high-density lipoprotein,and the increase of resting heart rate and the decrease of high-density lipoprotein increase the risk factors related to cardiovascular disease.Compared with normal women,PCOS patients have significantly thickened CIMT.