基于文献计量视角分析癫痫与生酮饮食的相关性研究

Analysis of correlation between epilepsy and ketogenic diet based on bibliometrics

目的通过CiteSpace对生酮饮食治疗癫痫相关文献的地区、机构、期刊、作者、被引次数和关键词进行分析,预测该领域研究最新趋势。方法以Web of Science中2002年—2022年8月13日收录的核心合集数据库为文献来源,应用CiteSpace 5.7.R2进行文献可视化分析,并绘制相关可视化图谱。结果筛选后共纳入2193篇文献。目前,生酮饮食治疗癫痫的相关研究处于快速上升阶段。美国是这一领域的主要推动力,提供了34.38%的出版物;中国发文量排第4位。最活跃的机构是约翰霍普金斯大学,引用频率最高的杂志是Cited Journal。共同被引文献最多的是Epilepsia Open杂志的文章。ERIC H KOSSOFF是最多产的作家,也是最常被共同引用的作者。“肠道微生物群”“微生物轴-肠脑轴”“改良阿特金斯饮食”和“基因突变”等为生酮饮食治疗癫痫的研究前沿。研究热点逐渐从局部病变部位扩展到其他部位,如从“大脑”到“微生物轴-肠脑轴”的转变,呈现多学科交叉的发展特点。结论生酮饮食和肠道微生物对癫痫治疗的结合应用是未来必然的发展趋势。

Objective To analyze the regions,institutions,journals,authors,citation times and keywords of literatures related to ketogenic diet for epilepsy through CiteSpace,and to predict the latest trends in this field.Methods The core collection database collected in Web of Science from 2002 to August 13,2022 was used as the literature source.CiteSpace 5.7.R2 was used for literature visualization analysis,and related visualization maps were drawn.Results A total of 2193 literatures were included after screening.At present,the related research of ketogenic diet for epilepsy was on the rise rapidly.The United States was the main driver in this area,providing 34.38 per cent of publications;China ranked the fourth in terms of the number of publications.The most active institution was Johns Hopkins University,and the most frequently cited journal was Cited Journal.The most commonly cited articles were those published in Epilepsia Open.ERIC H KOSSOFF was the most prolific author and the most frequently co-cited."Gut microbiome""microbiome axis-gut brain axis""modified Atkins diet"and"gene mutation"were the research frontiers of ketogenic diet treatment of epilepsy.The research focus had gradually expanded from the local lesion site to other sites,such as the transformation from"brain"to"microbial axis-enterobrain axis",showing the characteristics of multidisciplinary development.Conclusion The combined application of ketogenic diet and intestinal microbiome in epilepsy treatment is an inevitable trend in the future.