颈动脉狭窄患者轻度认知障碍患病率及影响因素的系统评价

Prevalence and influencing factors of mild cognitive impairment in patients with carotid artery stenosis:a systematic review

目的系统评价颈动脉狭窄患者轻度认知障碍患病率及影响因素。方法检索Embase、PubMed、CINAHL、Scopus、The Cochrane Library、Web of Science合集、CMB、中国知网、维普、万方数据库,搜集关于颈动脉狭窄轻度认知障碍的研究,检索时限为建库至2022年6月。采用Stata 16.0软件进行Meta分析,并对影响因素进行描述性分析。结果共纳入12项文献,包括3447例患者。Meta分析显示,颈动脉狭窄患者轻度认知障碍患病率为32%(95%CI:27%~37%)。亚组分析显示,60~70岁年龄段颈动脉狭窄患者轻度认知障碍患病率最高,男性患病率高于女性,且患病率近年来呈增高趋势。描述性分析显示,年龄、性别、高胆固醇血症、颈动脉狭窄程度、高血糖、吸烟、饮酒、受教育程度、高血压、心房颤动及高血脂等是颈动脉狭窄患者发生轻度认知障碍的影响因素。结论颈动脉狭窄患者轻度认知障碍患病率较高,高龄、男性、慢性病、受教育程度低等因素可增加颈动脉狭窄患者轻度认知障碍的发生风险。

Objective To systematically evaluate the prevalence and influence factors of mild cognitive impairment in patients with carotid artery stenosis.Methods Embase,PubMed,CINAHL,Scopus,The Cochrane Library,Web of Science,CMB,CNKI,VIP and WANFANG DATA were retrieved.Studies on mild cognitive impairment with carotid artery stenosis were collected,and the search period was from the establishment of the database to June 2022.Stata 16.0 software was used for meta-analysis and descriptive analysis of influencing factors.Results A total of 12 articles were included,including 3447 patients.Meta-analysis showed that the prevalence of mild cognitive impairment in patients with carotid artery stenosis was 32%(95%CI,27%to 37%).Subgroup analysis showed that the prevalence of mild cognitive impairment was the highest in patients with carotid artery stenosis aged 60 to 70 years,and the prevalence of mild cognitive impairment in males was higher than that in females,and the prevalence of mild cognitive impairment showed an increasing trend in recent years.Descriptive analysis showed that age,sex,hypercholesterolemia,degree of carotid artery stenosis,hyperglycemia,smoking,drinking,education level,hypertension,atrial fibrillation and hyperlipidemia were the influencing factors for mild cognitive impairment in patients with carotid artery stenosis.Conclusion The prevalence of mild cognitive impairment is higher in patients with carotid artery stenosis,and factors such as old age,male,chronic disease as well as low education level can increase the risk of occurrence mild cognitive impairment in patients with carotid artery stenosis.