夫精宫腔内人工授精临床妊娠率的相关影响因素分析

Analysis of related factors influencing pregnancy rate of intrauterine insemination with husband’s sperm

目的:探讨夫精宫腔内人工授精(intrauterine insemination,IUI)临床妊娠率的相关影响因素。方法:选取2019年1月-2022年2月安徽省第二人民医院生殖医学中心施行IUI治疗的129对夫妇,共183个周期,比较IUI患者的排卵方案、不孕因素、妊娠率等的差异性。结果:女方年龄<35岁组的妊娠率高于≥35岁组(P<0.05),促排卵方案的妊娠率高于自然排卵方案(P<0.05),体质量指数(BMI)<24 kg/m^(2)组的妊娠率高于BMI≥24~<28 kg/m^(2)组及BMI≥28 kg/m^(2)组(P<0.05),各不孕因素间妊娠率比较,差异有统计学意义(P<0.05);临床妊娠组与临床未妊娠组优势卵泡个数相比较,差异有统计学意义(P<0.05);多因素Logstic回归分析显示,优势卵泡个数可以作为提高临床妊娠率的独立临床因素(P<0.05)。结论:女方年龄<35岁、促排卵方案、体质量指数<24 kg/m^(2)组可提高IUI临床妊娠成功率,优势卵泡个数可以作为提高临床妊娠率的独立临床因素。

Objective:To investigate the related factors influencing the pregnancy rate of intrauterine insemination(IUI)with the husband’s sperm.Methods:From January 2019 to February 2022,129 couples underwent IUI treatment at the Reproductive Medicine Center of Anhui No.2 Provincial People's Hospital.There were 183 cycles in total.Differences in ovulation protocols,infertility factors,and pregnancy rates in patients under IUI were compared.Results:Pregnancy rates of women<35 years were higher than those women≥35 years(P<0.05),and pregnancy rates women under ovarian stimulation protocol were higher than women under natural ovulation protocols(P<0.05).Pregnancy rates of women with a BMI(body mass index)<24 kg/m^(2)were higher than those in the groups with BMI of≥24~<28 kg/m^(2)group and BMI≥28 kg/m^(2)(P<0.05).The pregnancy rates influenced by different factors were compared and the differences were statistically significant(P<0.05).There was statistical significance in the number of dominant follicles between the pregnancy group and non-pregnancy group(P<0.05).Multivariate Logstic regression analysis showed that the number of dominant follicles could be an independent factor to improve the clinical pregnancy rate(P<0.05).Conclusion:Female age<35 years,ovulation stimulation protocol,and BMI<24 kg/m^(2)could improve the success rate of pregnancy under IUI(P<0.05),and the number of dominant follicles could be an independent factor to increase the clinical pregnancy rate(P<0.05).