非小细胞肺癌患者认知功能和生命质量的影响因素分析

Influencing factors of cognitive function and quality of life in patients with non-small cell lung cancer

目的探讨非小细胞肺癌(non small cell lung cancer,NSCLC)患者认知功能和生命质量的改变情况。方法采用MMSE量表和EORTC QLQ-C30生命质量调查问卷评估141例NSCLC患者,分析认知功能和生命质量的影响因素。结果141例NSCLC患者中,认知功能障碍的发生率55.32%。单因素分析显示年龄、教育程度、脑病灶放疗、体育锻炼、基础疾病在患者的认知功能障碍发生情况下比较,差异均有统计学意义(P<0.05)。认知功能障碍组定向力、记忆力、注意和计算力、回忆能力、语言能力均低于认知功能正常组(P<0.05)。多因素Logistic回归分析显示年龄≥60岁、有基础疾病是NSCLC患者发生认知功能障碍的危险因素(P<0.05),教育程度高、适当体育锻炼是NSCLC患者发生认知功能障碍的保护因素(P<0.05)。多元回归分析显示年龄大、教育程度低、贫血、病情知晓、化疗周期长、合并其它疾病、脑病灶放疗的患者的生命质量较差(P<0.05)。结论NSCLC患者在诊治过程中,大多出现认知功能障碍和生命质量下降,影响因素较多。专业量表评估后采用针对性干预措施可改善认知功能和提高生命质量。

Objective To investigate the changes of cognitive function and quality of life in patients with non-small cell lung cancer(NSCLC).Methods The MMSE scale and EORTC QLQ-C30 Quality of Life questionnaire were used to evaluate 141 patients with NSCLC,and the related influencing factors of cognitive function and quality of life were analyzed.Results The incidence of cognitive dysfunction was 55.32%in 141 patients with NSCLC.Univariate analysis showed that there were statistically significant differences in age,education level,radiotherapy for brain lesions,physical exercise and underlying diseases in the occurrence of cognitive dysfunction(P<0.05).The orientation,memory,attention and calculation,recall and language ability of the cognitive dysfunction group were lower than those of the normal cognitive function group(P<0.05).Multivariate Logistic regression analysis showed that age≥60 years old and underlying diseases were risk factors for cognitive dysfunction in NSCLC patients(P<0.05),and high education level and appropriate physical exercise were protective factors for cognitive dysfunction in NSCLC patients(P<0.05).Multiple regression analysis showed that the quality of life of patients with older age,lower education level,anemia,disease awareness,chemotherapy based treatment,long chemotherapy cycle,and other diseases were worse(P<0.05).Conclusion Cognitive dysfunction and decreased quality of life are common in NSCLC patients during treatment.The use of targeted intervention measures after professional scale assessment can improve cognitive function and quality of life.