NLR、维生素D水平在类风湿关节炎的诊断价值及与疾病活动度的相关性

Diagnostic value of NLR and vitamin D levels in rheumatoid arthritis and their correlation with disease activity

目的 分析NLR、维生素D检测在类风湿关节炎的诊断及其与疾病活动度的相关性。方法 选取2020年1月至2022年6月亳州市人民医院收治的128例类风湿关节炎患者作为观察组,选取于内分泌科、血液科、生殖医学门诊进行检查的106例患者作为对照组,对比两组患者NLR、维生素D水平,通过绘制ROC曲线分析NLR、维生素D水平对类风湿关节炎的诊断价值;并对比不同疾病活动度的类风湿关节炎的患者的NLR、维生素D水平差异,采用Spearman分析NLR、维生素D水平与类风湿关节炎疾病活动度的的相关性。结果 观察组患者的NLR明显高于对照组,维生素D水平明显低于对照组,差异具有统计学意义(t=16.560、20.614,P<0.05)。ROC曲线分析结果显示,NLR、维生素D水平及联合诊断类风湿关节炎曲线下面积分别为0.968、0.954、0.993。NLR水平:高疾病活动度>中等疾病活动度>低疾病活动度,差异有统计学意义(F=258.00,P<0.05);维生素D水平:低疾病活动度>中等疾病活动度>高疾病活动度,差异有统计学意义(F=103.19,P<0.05)。Spearman相关分析显示,NLR水平与RA疾病活动度呈正相关(r=0.889,P<0.001);维生素D水平与RA疾病活动度呈负相关(r=-0.711,P<0.001)。结论 NLR、维生素D检测对类风湿关节炎的诊断均具有一定价值,联合诊断的效能更佳,且NLR、维生素D与类风湿关节炎的疾病活动度具有明显的相关性。

Objective To analyze the correlation between NLR and vitamin D detection in the diagnosis of rheumatoid arthritis and disease activity.Methods A total of 128 patients with rheumatoid arthritis admitted to the People ' s Hospital of Bozhou from January 2020 to June 2022 were retrospectively selected as the observation group,and 106 patients who underwent examination in the Department of Endocrinology,Hematology and Reproductive Medicine clinics were selected as the control group.The levels of NLR and vitamin D were compared between the two groups.ROC curve was drawn to analyze the diagnostic value of NLR and vitamin D levels in rheumatoid arthritis.The differences of NLR and vitamin D levels in patients with rheumatoid arthritis with different disease activity levels were compared,and the correlation between NLR and vitamin D levels and disease activity of rheumatoid arthritis was analyzed by Spearman.Results NLR and vitamin D levels in the observation group were significantly higher than those in the control group,and the difference was statistically significant(t=16.560、20.614,P<0.05).ROC curve analysis results showed that NLR,vitamin D level and the area under the curve of combined diagnosis of rheumatoid arthritis were 0.968,0.954 and 0.993,respectively.NLR level:high disease activity moderate disease activity low disease activity,the difference was statistically significant(F=258.00,P<0.05).Vitamin D level:low disease activity moderate disease activity high disease activity,the difference was statistically significant(F=103.19,P<0.05).Spearman correlation analysis showed that NLR level was positively correlated with RA disease activity(r=0.889,P<0.001).Vitamin D levels were negatively correlated with disease activity in RA(r=-0.711,P<0.001).Conclusion The detection of NLR and vitamin D has certain value in the diagnosis of rheumatoid arthritis,and the efficiency of combined diagnosis is better,and there is a significant correlation between NLR,vitamin D and the disease activity of rheumatoid arthritis.