三金汤治疗对输尿管上段嵌顿性结石术后患者CRP、LPS及PCT水平的影响

Effect of Sanjin Decoction on CRP,LPS and PCT levels in postoperative patients with upper ureteral impacted calculi

目的 研究三金汤治疗对输尿管上段嵌顿性结石术后患者C-反应蛋白(CRP)、脂多糖(LPS)、血清降钙素原(PCT)水平的影响。方法 选取邯郸市磁县人民医院自2019年2月至2021年12月间收治的350例输尿管上段嵌顿性结石患者,根据治疗方法不同分成单纯碎石组(软镜碎石取石治疗,n=171)、碎石+三金汤组(软镜碎石取石+三金汤治疗,n=179),比较两组CRP、LPS及PCT水平变化、结石残存率、住院时间、生活质量水平、并发症发生率。结果 治疗后,碎石+三金汤组CRP、LPS、PCT水平均低于单纯碎石组,差异有统计学意义(t=55.694、5.086、7.043,P<0.05);治疗2个月后,碎石+三金汤组结石残存率(0.56%)低于单纯碎石组(7.60%),住院时间短于单纯碎石组,差异有统计学意义(χ^(2)=11.299、t=84.119,P<0.05);碎石+三金汤组患者SF-36评分(84.71±8.62)高于单纯碎石组(77.45±7.93),差异有统计学意义(t=8.190,P<0.05);碎石+三金汤组血尿、感染等并发症总并发率6.15%,低于单纯碎石组的16.96%,差异有统计学意义(χ^(2)=10.103,P<0.05)。结论 采用三金汤治疗输尿管上段嵌顿性结石术患者,能改善机体CRP、LPS、PCT水平,降低结石复发率。

Objective To study the effects of Sanjin Decoction on C-reactive protein(CRP),lipopolysaccharide(LPS)and serum procalcitonin(PCT)levels in patients with upper ureteral incarcerated calculi after operation.Methods 350 patients with incarcerated calculi in the upper ureter admitted to the People's Hospital of Cixian County of Handan City from February 2019 to December 2021 were selected,and according to different treatment methods,they were divided into the simple lithotripsy group(soft mirror lithotripsy treatment,n=171) and the lithotripsy + Sanjin decoction group(soft mirror lithotripsy + Sanjin decoction treatment,n=179),the levels of CRP,LPS and PCT,stone survival rate,length of hospital stay,quality of life,and complication rate were compared between the two groups.Results After treatment,the levels of CRP,LPS and PCT in the lithotripsy + Sanjin decoction group were lower than those in the lithotripsy group,and the difference was statistically significant(t=55.694,t=5.086,t=7.043,P<0.05).2 months after treatment,the stone survival rate in the lithotripsy + Sanjin decoction group(0.56%)was lower than that in the lithotripsy group(7.60%),and the length of hospital stay in the lithotripsy + Sanjin decoction group was shorter than that in the lithotripsy group,and the difference was statistically significant(χ^(2)=11.299,t=84.119,P<0.05).The SF-36 score in the lithotripsy + Sanjin Decoction group(84.71 ± 8.62)was higher than that in the lithotripsy group(77.45 ± 7.93),and the difference was statistically significant(t=8.190,P<0.05).The total complication rate of hematuria and infection in the lithotripsy + Sanjin Decoction group was 6.15%,which was lower than that in the lithotripsy group(16.96%),and the difference was statistically significant(χ^(2)=10.103,P<0.05).Conclusion The use of Sanjin Decoction in the treatment of patients with upper ureteral incarcerated calculi can improve the levels of CRP,LPS and PCT,and decrease the recurrence rate of calculi.