摘要
骨质疏松症是一种常见的代谢性骨病,发病率逐年增高,严重威胁老年人群的健康。Wnt/β-catenin信号通路参与调节骨量、调节间充质干细胞向成骨细胞分化的关键环节,在骨质疏松发生发展中发挥重要作用,在干细胞研究和骨质疏松再生医学中具有很高的临床应用价值。本文结合国内外最新研究进展,在总结Wnt/β-catenin信号通路进展与转导机制的基础上,探讨了Wnt/β-catenin信号通路活性在骨质疏松症环境下调控骨髓间充质干细胞促进成骨、抑制成脂过程发挥的作用,以期为临床治疗和预防提供参考,以更好应对我国老龄化公共卫生挑战。
Osteoporosis is a common metabolic bone disease.The incidence rate of osteoporosis is increasing year by year,which seriously threatens the health of the elderly.Wnt/β-catenin is considered to be one of the important signal pathways regulating bone mass and plays a crucial role in regulating the differentiation of mesenchymal stem cells into osteoblasts.It has important clinical application value in regenerative medicine and stem cell research.This review combines the latest research progress on the basis of summarizing the progress and transduction mechanism of Wnt/β-catenin signal pathway,and discussing the role of the change of Wnt/β-catenin pathway activity in regulating the role of BMSCs in promoting osteogenesis and inhibiting adipogenesis in osteoporosis,to provide reference for clinical treatment and prevention,to better respond to the public health challenges of aging in China.
作者
王浩阗
邵阳
汪国澎
叶灵山
王秋波
王建伟
WANG Haotian;SHAO Yang;WANG Guopeng;YE Lingshan;WANG Qiubo;WANG Jianwei(Nanjing University of Chinese Medicine,Wuxi,Jiangsu,China,210023;Orthopedics and Traumatology Department,Wuxi Hospital of Traditional Chinese Medicine,Wuxi,Jiangsu,China,214071;Clinical Laboratory,the Ninth People's Hospital of Wuxi,Wuxi,Jiangsu,China,214062)
出处
《分子诊断与治疗杂志》
2023年第4期720-724,共5页
Journal of Molecular Diagnostics and Therapy
基金
无锡市卫生健康委科研项目(Q201945)。
