基于文献数据库的药物诱导的抑郁动物模型的研究进展

Literature review of animal models of depression induced by drugs

抑郁症是一种严重危害人类身心健康的疾病,建立良好的抑郁症动物模型对其发病机制的研究及抗抑郁药物研发具有重要的意义。在抑郁症动物模型中,药物诱导抑郁动物模型因操作简便、节省时间等优点而被广泛使用。本文通过系统查阅中国知网(CNKI)和PubMed两大数据库,对自建库起至2021年7月1日以来关于药物诱导的抑郁症动物模型的文献进行分析整理,综述了六种常用的药物诱导抑郁动物模型的使用频次、造模动物选择、药物注射剂量和注射方式、模型的评价指标以及优缺点等方面,以期为抑郁症动物模型的制备及相应的药物研发提供参考。

Depression is a disease that seriously endangers human physical and mental health.The establishment of a suitable animal model of depression is of great significance to study its pathogenesis and develop drugs.Among the animal models of depression,animal models of drug⁃induced depression are widely used because of the advantages of simplicity and timely establishment.This article systematically reviewed drug⁃induced depression animal models in the China National Knowledge Network and PubMed until July 1,2021,and reviewed six commonly used drug⁃induced depression animal models.The frequency of use of induced depression animal models,selection of model animals,drug injection dosage,injection method,indicators for model evaluation,advantages,and disadvantages are expected to provide references to prepare depression models and develop drugs.