摘要
以醋酸钯、1,1’-联萘-2,2’-双二苯膦(BINAP)为催化剂,二甲苯为溶剂,氟代偕二醇砌块在碳酸钾的作用下,脱三氟乙酸后与溴代芳烃发生芳基化反应,于130℃反应7 h,合成了一系列α-氟代芳基酮类化合物,收率最高可达96%,其结构经^(1)H NMR,^(13)C NMR,^(19)F NMR和HR-MS(ESI)表征。
A series ofα-fluorinated arones were synthesized by arylation of fluorinated gem-diols catalyzed by Pd(OAc)_(2)and 1,1’-binaphthyl-2,2’-diphemyl phosphine(BINAP)in xylene at 130℃for 7 h,and using K_(2)CO_(3)as the base.The yields of products were up to 96%.The structures of compounds were characterized by^(1)H NMR,^(13)C NMR,^(19)F NMR and HR-MS(ESI).
作者
徐利军
李若阳
罗艳红
徐金球
XU Lijun;LI Ruoyang;LUO Yanhong;XU Jinqiu(Shanghai Engineering Research Center of Advanced Thermal Functional Materials,School of Resources and Environmental Engineering,Shanghai Polytechnic University,Shanghai 201209,China)
出处
《合成化学》
CAS
2023年第5期368-375,共8页
Chinese Journal of Synthetic Chemistry
基金
上海市青年科技英才扬帆计划(19YF1416500)
上海第二工业大学校基金资助项目(EGD19XQD17、EGD22DS09)。
关键词
钯催化
芳基化
α-氟代芳基酮
1
1’-联萘-2
2’-双二苯膦
含氟砌块
palladium-catalysis
arylation
α-fluorinated arone
1,1’-binaphthyl-2,2’-diphemyl phosphine
fluorine-containing building blocks
