DNA甲基化与非大动脉粥样硬化型卒中相关性研究进展

Advances in Correlation between DNA Methylation and Non-Large Artery Atherosclerotic Stroke

缺血性卒中由多种环境因素和遗传风险因素共同决定。DNA甲基化作为一种重要的表观遗传学调控机制,可能是缺血性卒中的可遗传危险因素,对缺血性卒中的发生、发展过程产生潜在影响。缺血性卒中不同病因亚型存在特征性候选基因DNA甲基化水平改变,这对探究不同病因亚型的病理生理学过程具有重要价值。DNA甲基化是动态、可逆的表观遗传学改变,其模式可随疾病发生、发展的不同时期发生显著变化,提示DNA甲基化可作为缺血性卒中及其亚型的潜在生物标志物和治疗靶点。本文就DNA甲基化与非大动脉粥样硬化型(心源性栓塞型、小动脉闭塞型、其他明确病因型)卒中的关系进行综述,以期为缺血性卒中的诊断和治疗提供新思路。

Ischemic stroke is determined by a variety of environmental and genetic risk factors.As a critical epigenetic regulatory mechanism,DNA methylation may be a heritable risk factor and potentially influence the occurrence and development of ischemic stroke.There are changes in DNA methylation levels of characteristic candidate genes in different etiological subtypes of ischemic stroke,which is important value in exploring the pathophysiological processes of different stroke subtypes.DNA methylation is a dynamic and reversible epigenetic change,and its pattern can change significantly with different stages of disease,suggesting that DNA methylation can be a potential biomarker and therapeutic target for ischemic stroke and its subtypes.This article reviewed the correlation between DNA methylation and non-large artery atherosclerotic stroke(cardioembolism,small-artery occlusion and other determined etiology),to provide new ideas for the diagnosis and treatment of ischemic stroke.