DNA甲基化与高同型半胱氨酸血症

DNA Methylation and Hyperhomocysteinemia

DNA甲基化是一种调控基因表达的表观遗传机制,由Hcy代谢相关底物S-腺苷同型半胱氨酸(S-adenosyl-L-homocysteine,SAH)依赖性的DNA甲基转移酶(DNA methyltransferases,DNMTs)催化,对维持细胞稳态至关重要。多项研究表明,高同型半胱氨酸血症(hyperhomocysteinemia,HHcy)可能通过调节甲硫氨酸-同型半胱氨酸循环(methionine-homocysteine cycle,M-H cycle)调控DNA甲基化状态,参与动脉粥样硬化形成过程中的血管内皮细胞功能障碍、损伤后平滑肌细胞(smooth muscle cells,SMCs)的增殖和转移、脂质代谢等病理过程,从而影响心血管疾病的发生和预后。

DNA methylation is a process catalyzed by DNA methyltransferases(DNMTs),which is dependent on S-adenosyl-L-homocysteine(SAH),a substrate related to the metabolism of Hcy.It is an epigenetic mechanism that regulates gene expression,and is critical for maintaining cellular homeostasis.A number of studies have shown that hyperhomocysteinemia(HHcy)may regulate DNA methylation status by regulating the methionine-homocysteine cycle(M-H cycle),which is involved in multiple pathological process of atherosclerosis formation such as dysfunction of endothelial cells,proliferation and metastasis of damaged smooth muscle cells(SMCs),and lipid metabolism,then can influence the occurrence and prognosis of cardiovascular diseases.