布地奈德福莫特罗治疗慢阻肺合并肺癌稳定期患者的临床疗效

Clinical Effect of Budesonide and Formoterol in Treatment of Chronic Obstructive Pulmonary Disease Patients with Lung Cancer at Stable Stage

目的 探究慢阻肺合并肺癌稳定期患者经布地奈德福莫特罗治疗的临床疗效。方法 选取2019年1月-2021年12月东莞市滨海湾中心医院接受治疗的慢阻肺合并肺癌稳定期患者31例,随机将患者分为对照组15例与研究组16例,对照组患者采取常规治疗,研究组在对照组基础上采取布地奈德福莫特罗粉吸入剂治疗,对治疗前后两组患者炎性因子、肺功能指标、生活质量评分、治疗效果及不良反应发生情况进行比较分析。结果 两组患者IL-8、IL-6在治疗前对比,差异无统计学意义(P>0.05),治疗后2组IL-8、IL-6均改善,研究组改善效果明显,差异有统计学意义(P<0.05);两组FEV1、FVC及FEV1/FVC治疗前对比,差异无统计学意义(P>0.05),治疗后两组FEV1、FVC及FEV1/FVC均改善,研究组改善效果明显,差异有统计学意义(P<0.05);治疗后两组患者生活质量评分对比,研究组明显较对照组高,差异有统计学意义(P<0.05);研究组治疗总有效率为,明显高于对照组低,差异有统计学意义(P<0.05);两组不良反应发生率对比,异无统计学意义(P>0.05)。结论 慢阻肺合并肺癌稳定期患者经常规治疗加用布地奈德福莫特罗粉吸入剂治疗可使患者肺功能尽快恢复,改善炎性因子水平,有利于提高患者生活质量,效果显著。

Objective To investigate clinical effect of budesonide fomotrol in treatment of chronic obstructive pulmonary disease(COPD)patients with lung cancer at stable stage.Methods The paper chose 31 cases chronic obstructive pulmonary disease(COPD)patients complicated with lung cancer at stable stage treated in Dongguan City Binhai Bay Central Hospital,and divided them into control group of 15 cases and study group of 16 cases randomly.Control group was treated with routine therapy,and study group with budesonide and formoterol powder inhalation on the basis of control group.Inflammatory factors,lung function indicators,life quality scores,treatment effect and adverse reactions were compared and analyzed.Results There was no statistically significant difference in IL-8 and IL-6 between two groups before treatment(P>0.05).After treatment,both IL-8 and IL-6 in two groups were higher,improvement effect in study group was significant,with statistically significant difference(P<0.05).There was no statistically significant difference in FEV1,FVC,and FEV1/FVC between two groups before treatment(P>0.05).After treatment,FEV1,FVC,and FEV1/FVC in two groups improved significantly,with statistically significant difference(P<0.05).After treatment,life quality scores of two groups in study group were significantly higher than control group,with statistically significant difference(P<0.05).Total effective rate of study group was significantly higher than control group,with statistically significant difference(P<0.05).There was no statistically significant difference in adverse reactions incidence between two groups(P>0.05).Conclusion Regular treatment with budesonide and formoterol powder inhalation can restore lung function of chronic obstructive pulmonary disease(COPD)patients complicated with lung cancer at stable stage as soon as possible,improve level of inflammatory factors and life quality with significant effect.