分析自拟胸痹散对冠心病心绞痛(阳气虚衰型)患者的临床疗效及儿茶酚胺水平的影响

Clinical Effect and Catecholamine Levels Analysis of Self-Designed Chest Obstruction Powder dor Patients with Coronary Heart Disease Angina Pectoris(Yang Qi Deficiency Type)

目的 通过挖掘经典古籍,整合名家临床经验自拟胸痹散,观察该治疗措施在冠心病心绞痛(阳气虚衰型)治疗中的应用价值,旨在帮助患者获得最佳治疗效果,进而为后续自拟胸痹散的疾病治疗工作提供科学指导。方法 本研究选取潮州市中医院门诊或住院的符合西医冠心病及中医阳气虚衰型诊断标准的40例患者,入选患者近一月未吸烟饮酒,并签署知情同意书,高血压、糖尿病患者行常规治疗;利用随机数字表法将40例患者分为试验组、对照组,每组各20例。治疗上,对照组实施常规治疗,试验组在常规西物治疗基础上加自拟胸痹散。记录试验组、对照组第1天及第22天各项指标并分析参与患者的中医症状积分表、西雅图心绞痛量表、血清儿茶酚胺水平。结果 冠心病心绞痛(阳气虚衰型)症状改善,试验组效果优于对照组治疗,且试验组的中医症状积分更低,试验组的西雅图心痛量表得分更高,两者差异有统计学意义(P<0.05);试验组儿茶酚胺水平下降程度大于对照组,差异有统计学意义(P<0.05)。结论 自拟胸痹散对冠心病心绞痛(阳气虚衰型)患者症状有明显改善作用,效果优于常规西药治疗,故于临床推广该自拟药散有临床应用意义。自拟胸痹散实施后试验组患者茶酚胺水平下降程度大于对照组,其治疗作用可能与儿茶酚胺调控相关。

Objective To explore classic ancient books and integrate clinical experience of famous experts,develop self made Chest Obstruction Powder,and observe its application value for coronary heart disease angina pectoris(Yang Qi deficiency and failure type),and achieve the best treatment effect and provide scientific guidance for subsequent self developed Chest Obstruction Powder treatment.Methods The study chose 40 outpatients or inpatients of Chaozhou Traditional Chinese Medicine Hospital met diagnostic criteria of coronary heart disease in Western medicine and Yang Qi deficiency in Chinese medicine,selected patients did not smoke and drink in the past month,and signed an informed consent form.Hypertension and diabetes patients were routinely treated and included in the group,divided into experimental group and control group with random number table method,with 20 cases in each group.Control group was treated with routine treatment,while experimental group with self formulated chest obstruction powder on the basis of routine Western medicine treatment.Traditional Chinese Medicine Symptom Scores,Seattle Angina Pectoris Scale,and serum catecholamines of participating patients were recorded and analyzed on the 1st and 22nd days betewen experimental group and control group.Results Symptoms of coronary heart disease angina pectoris(Yang Qi deficiency type)improved,treatment effect of experimental group was better than control group.TCM symptom scores of experimental group wre lower,Seattle Heart Pain Scale scores were higher in experimental group,with statistically significant difference(P<0.05).Catecholamine levels decrease in experimental group was higher than control group,difference was statistically significant(P<0.05).Conclusion Self made chest obstruction powder can achieve significant improvement effect on patients with coronary heart disease angina pectoris(Yang Qi deficiency type),with better effect than routine Western medicine treatment.Therefore,self made powder has clinical application significance in clinical practice.After application of self designed chest pain powder,catecholamine levels decrease in experimental group was greater than control group,whose curative effect may be related to regulation of catecholamines.