一种改良的连续操作测试及临床评价

A modified continuous performance test and its clinical evaluation

目的 构建一种改良的连续操作测试(CPT),改善经典CPT在面向健康受试者存在区分度不足、考察维度相对狭窄的问题,并进行临床评价。方法 30名健康受试者在同一时间段完成3个版本CPT的测试,CPT1为经典版本CPT,CPT2在CPT1基础上增加选择性注意力的考核,CPT3在CPT2的基础上将固定时间间隔改为随机时间间隔。观察受试者的正确反应时间、正确数、错误数、遗漏数,通过折半和重复信度考察可靠性。结果 3个版本CPT中,CPT1的正确率最高,正确反应时间最短,错误率与遗漏率最低。与CPT1相比,CPT2和CPT3的正确率降低,正确反应时间增加,错误率与遗漏率有不同程度的增加(P<0.01);CPT3正确率低于CPT2,错误率、遗漏率和正确反应时间显著高于CPT2(P<0.01)。CPT1和CPT2正确率分布集中在95%以上,分布狭窄,CPT3的正确率分布较CPT1、CPT2更宽。3个版本CPT的折半信度均大于0.8,CPT1、CPT2的重复信度均小于0.5,稳定性不足,而CPT3的重复信度为0.964。结论 改良版本CPT3是一个有效的注意力测试工具,它对特殊受试者人群的区分度更大,可以用于特殊场景下药物改善注意力的检测观察。

AIM A modified continuous performance test(CPT)was constructed to improve the problems of insufficient discrimination and relatively narrow examination dimensions of the classical CPT for healthy subjects,and to perform clinical evaluation.METHODS Thirty healthy subjects completed three versions of CPT at the same time period.CPT1 was the classic version of CPT.The selective attention assessment was added in the CPT2 on the basis of CPT1.And the fixed time interval changed to a random time interval in the CPT3 on the basis of CPT2.The correct response time,number of correct,number of errors,and number of omissions of the subjects were observed,and the reliability was examined through discounting by half and repeated reliability.RESULTS The CPT results of the three versions showed that CPT1 had the highest correct rate,the shortest correct reaction time,and extremely low error rate and omission rate.Compared with CPT1,the correct rate of CPT2 and CPT3 decreased,the correct reaction time increased,and the error rate and omission rate increased to varying degrees(P<0.01).The Correct rate of CPT3 was lower than that of CPT2,and the error rate,omission rate and the correct reaction time were significantly higher than those of CPT2.The distribution of correct rates for CPT1 and CPT2 was concentrated above 95% with a narrow distribution,and the distribution of correct rates for CPT3 was broader compared with that of CPT1 and CPT2.The split-half reliabilities of the three versions of CPT were all greater than 0.8.The repeated reliabilities of the CPT1 and CPT2 were both less than O.5,and the stabilities were insufficient.The repeated reliability of the CPT3 was 0.964.CONCLUSION The modified version CPT3 is a valid attention test tool.It has a greater discrimination for specific subject populations,and can be used for detection and observation of drug-improved attention in special scenes.