基于脾主运化探析健脾益气类中药调节脾气虚机体代谢紊乱的研究进展

Regulation of Metabolic Disorders in Piqixu(脾气虚) by Jianpi(健脾) Yiqi(益气) Chinese Medicine Based on the Principle of Pizhuyunhua(脾主运化):A Review

中医理论提及脾主运化,脾功能失司常会导致机体糖代谢、蛋白质代谢、能量代谢、脂代谢、等发生紊乱,造成机体的物质能量代谢异常,进而引发高血压、血糖异常、血脂紊乱、肥胖症、非酒精性脂肪肝、Ⅱ型糖尿病、等代谢性疾病。临床上常用黄芪、人参、四君子汤、补中益气汤等健脾益气方药治疗脾气虚证。近年来,诸多学者通过研究表明脾气虚证机体存在代谢异常,且通过健脾益气类中药干预可调整代谢。本文从脾气虚与机体代谢紊乱关系、健脾益气类中药调节脾气虚机体代谢紊乱的研究现状进行综述,为阐明健脾益气类中药调节脾气虚机体代谢紊乱的可能机制提供参考。

According to the Pizhuyunhua(脾主运化)in traditional Chinese medicine,the malfunction of Pi(脾)will lead to metabolic disorders of glucose,protein,energy,and lipid,further resulting in metabolic diseases such as hypertension,pathoglycemia,dyslipidemia,obesity,non-alcoholic fatty liver,and type II diabetes.In clinical settings,Jianpi(健脾)Yiqi(益气)medicines,such as Huangqi(黄芪),Renshen(人参),Sijunzi(四君子)Decoction,and Buzhong Yiqi(补中益气)Decoction,are commonly used to treat Piqixu(脾气虚)syndrome.Inrecent years,metabolic disorders have been frequently verified in Piqixu syndrome and Jianpi Yiqi Chinese medicines can be used to regulate the disorders.This paper reviews the relationship between Piqixu and metabolic disorders and the regulation of metabolic disorders in Piqixu by Jianpi Yiqi Chinese medicines,which is expected to serve as a reference for elucidating the mechanism underlying the alleviation of metabolic disorders in Piqixu by Jianpi Yiqi Chinese medicines.