子午流注纳支法联合加味四黄散治疗肝胆湿热型肝癌癌痛的临床效果

Clinical Effect of the Treatment of Liver and Gallbladder Dampness-heat Type Liver Cancer Pain by Means of Meridian Flow and Nanzhi Method Combined with Modified Sihuang Powder

目的探讨子午流注纳支法联合加味四黄散治疗肝胆湿热型肝癌癌痛的临床效果。方法选取2021年5月至2022年5月广州医科大学附属中医医院收治的100例肝胆湿热型肝癌癌痛患者作为研究对象,按随机双盲对照法将其分为观察组与对照组,各50例。对照组开展子午流注纳支法联合安慰剂治疗,观察组则开展子午流注纳支法联合加味四黄散治疗。比较两组静息及运动状态下的疼痛情况,中医证候疗效,不良反应发生情况,治疗前后生命质量情况。结果治疗后观察组静息及运动状态下疼痛数字评价量表(NRS)评分均低于对照组(P<0.05)。在中医证候疗效总有效率方面对比,观察组高于对照组(P<0.05)。两组皮疹、恶心以及便秘发生率比较差异无统计学意义(P>0.05)。治疗后两组生命质量评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论子午流注纳支法联合加味四黄散治疗肝胆湿热型肝癌癌痛临床效果显著,可明显缓解患者疼痛,且不会增加不良反应发生风险,有助于患者生命质量的提升。

Objective To explore the clinical effect of the treatment of liver and gallbladder dampness-heat type liver cancer pain by means of meridian flow and nanzhi method combined with modified Sihuang powder.Methods 100 patients with hepatobiliary damp-heat cancer pain admitted to Affiliated Hospital of traditional Chinese medicine,Guangzhou Medical University from May 2021 to May 2022 were selected.They were divided into observation group(n=50)and control group(n=50)by randomized double-blind control method.The control group was treated with meridian flow and nanzhi method combined with placebo,while the observation group was treated with meridian flow and nanzhi method combined with modified Sihuang powder.The two groups were compared in terms of pain,TCM syndrome and curative effect,occurrence of adverse reactions and quality of life before and after treatment.Results After treatment,the NRS score of the observation group was lower than that of the control group at rest and during exercise(P<0.05).The effective rate of TCM syndromes was higher in the observation group than in the control group(P<0.05).There was no significant difference in the incidence of rash,nausea and constipation between the two groups(P>0.05).After treatment,the score of quality of life in the two groups was higher than that before treatment,and the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion Meridian flow and nanzhi method combined with modified Sihuang powder has significant clinical effect in the treatment of liver and gallbladder damp-heat type liver cancer pain,which can significantly relieve the pain of patients without increasing the risk of adverse reactions,and contribute to the improvement of patients'quality of life.