微生态制剂治疗溃疡性结肠炎患者的临床疗效观察

Clinical observation of microecological preparation in the treatment of patients with ulcerative colitis

目的分析溃疡性结肠炎患者采用微生态制剂治疗的临床效果。方法100例溃疡性结肠炎患者,按照随机数字表法分为研究组和对照组,每组50例。研究组患者给予微生态制剂治疗,对照组患者给予常规治疗。比较两组患者治疗前及治疗后3、6个月溃疡性结肠炎疾病活动指数(DAI),临床疗效,治疗6个月后结肠炎症状评分。结果治疗后3、6个月,研究组患者DAI分别为(1.8±1.5)、(1.4±1.7)分,低于对照组的(5.4±1.7)、(3.9±1.4)分,差异具有统计学意义(P<0.05)。研究组患者治疗总有效率为94.0%(47/50),高于对照组的76.0%(38/50),差异具有统计学意义(P<0.05)。治疗后6个月,研究组患者结肠炎症状评分为(1.57±0.36)分,低于对照组的(2.28±0.33)分,差异具有统计学意义(P<0.05)。结论对溃疡性结肠炎患者采用微生态制剂进行治疗效果显著,不仅能够显著降低患者的DAI,而且还能够改善患者的临床症状,值得临床研究和推广。

Objective To analyze the clinical effect of microecological preparation in the treatment of patients with ulcerative colitis.Methods A total of 100 patients with ulcerative colitis were divided into research group and control group according to the random numerical table,with 50 cases in each group.Patients in the research group were treated with microecological agents,and patients in the control group were treated with conventional treatment.The disease activity index(DAI)before treatment and 3 and 6 months after treatment,clinical efficacy,and colitis symptom score at 6 months after treatment were compared between the two groups.Results At 3 and 6 months after treatment,DAI of patients in the research group were(1.8±1.5)and(1.4±1.7)points,which were lower than those of(5.4±1.7)and(3.9±1.4)points in the control group,and the differences were statistically significant(P<0.05).The total effective rate of the research group was 94.0%(47/50),which was higher than that of 76.0%(38/50)of the control group,and the difference was statistically significant(P<0.05).At 6 months after treatment,the colitis symptom score in the research group was(1.57±0.36)points,which was lower than that of(2.28±0.33)points in the control group,and the difference was statistically significant(P<0.05).Conclusion Microecological preparation is effective on patients with ulcerative colitis,which can not only significantly lower the DAI,but also can improve the clinical symptoms of patients,which is worthy of clinical research and promotion.