喹硫平联合丙戊酸钠治疗双相情感障碍躁狂发作的疗效及对认知功能的影响

Efficacy of quetiapine combined with sodium valproate in the treatment of manic episodes of bipolar disorder and its influence on cognitive function

目的分析双相情感障碍躁狂发作患者应用喹硫平联合丙戊酸钠治疗的临床疗效以及对患者认知功能的影响。方法84例双相情感障碍躁狂发作患者,采取随机数字表法分为观察组和对照组,每组42例。对照组患者应用丙戊酸钠片治疗,观察组患者在对照组基础上联合应用富马酸喹硫平片治疗。比较两组患者治疗前后的贝克-拉范森躁狂量表(BRMS)评分、认知功能以及临床疗效。结果治疗后8周,观察组患者BRMS评分(7.27±3.22)分低于对照组的(13.22±4.06)分,差异有统计学意义(P<0.05)。观察组治疗总有效率95.24%高于对照组的78.57%,差异有统计学意义(P<0.05)。治疗后,观察组患者持续错误数(7.88±1.79)、错误应答数(38.47±4.02)、持续应答数(31.31±2.90)低于对照组的(10.58±1.92)、(43.33±4.23)、(37.27±3.59),完成分类数(4.04±0.72)高于对照组的(3.14±0.62),差异均有统计学意义(P<0.05)。结论喹硫平联合丙戊酸钠治疗双相情感障碍躁狂发作患者可以较好地改善躁狂症状,同时可改善患者认知功能,值得推广。

Objective To analyze the clinical efficacy of quetiapine combined with sodium valproate in the treatment of manic episodes of bipolar disorder and its influence on cognitive function.Methods A total of 84 patients with manic episodes of bipolar disorder were divided into observation group and control group according to the random numerical table,with 42 cases in each group.The control group was treated with sodium valproate tablets,and the observation group was treated with quetiapine fumarate tablets on the basis of the control group.The Bech-Rafaelsen Mania Rating Scale(BRMS)score before and after treatment,cognitive function,and clinical efficacy of the two groups were compared.Results At 8 weeks after treatment,BRMS score of the observation group was(7.27±3.22)points,which was lower than that of(13.22±4.06)points of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 95.24%,which was higher than that of 78.57%of the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had number of perseverative errors of(7.88±1.79)errors,error response of(38.47±4.02)and perseverative response of(31.31±2.90),which were lower than those of(10.58±1.92),(43.33±4.23)and(37.27±3.59)in the control group;the number of completed classification(4.04±0.72)in the observation group was higher than that of(3.14±0.62)in the control group;the differences were statistically significant(P<0.05).Conclusion Quetiapine combined with sodium valproate can improve the symptoms of mania and cognitive function of patients with manic episodes of bipolar disorder,which is worth promoting.