硫酸镁联合硝苯地平治疗重度子痫前期效果与不良反应分析

Effect and adverse reactions of magnesium sulfate combined with nifedipine in the treatment of severe preeclampsia

目的 探讨硫酸镁联合硝苯地平治疗重度子痫前期效果与不良反应。方法 选取重度子痫前期患者50例,以随机数字表法分为对照组与研究组,对照组25例单用硫酸镁,研究组25例联合硝苯地平,对比两组的效果及不良反应。结果研究组临床总有效率高于对照组;与治疗前比,治疗后两组舒张压、收缩压、24 h尿蛋白、心率、血清肌酐、尿素氮水平均降低,且研究组更低;研究组各项不良妊娠结局发生率均低于对照组,差异具有统计学意义(P<0.05)。结论 重度子痫前期在硫酸镁给药基础上给予硝苯地平联用,可提升总有效率,降低血压水平,维持24 h尿蛋白、心率稳定,改善肾功能,改善不良妊娠结局,且具较高的安全性。

Objective To investigate the effects and adverse reactions of nifedipine combined with magnesium sulfate administration in severe preeclampsia.Methods 50 patients with severe preeclampsia were selected and divided into the control group and the study group by random number table method.In the control group,25 patients were given magnesium sulfate alone,and in the study group,25 patients were given nifedipine combined.The effects and adverse reactions of the two groups were compared.Results The total clinical eflFective rate of the study group was higher than that of the control group.Compared with before treatment,diastolic blood pressure,systolic blood pressure,24 h urinary protein,heart rate,serum creatinine and urea nitrogen levels decreased in both groups after treatment,and the study group was lower.The incidence of total adverse pregnancy outcomes in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In severe preeclampsia,nifedipine combined with magnesium sulfate can enhance the total effective rate,reduce blood pressure,maintain the stability of24 h urinary protein and heart rate,improve renal function,reduce adverse pregnancy outcomes,and has high safety.