摘要
源于中药活性成分的新药创制是我国创新药物研发的特色和优势领域,但目前仍然存在药效物质基础不清、作用靶标和机制不明确等问题,极大阻碍了中药活性成分向新药物的临床转化。该文在分析整理当前我国创新药物研发现状及进展的基础上,针对中药活性成分发展前景及面临的困境,探讨实现中药活性成分高效发现,获得化学结构新颖、作用靶标/机制独特且具有自主知识产权的候选药物,以期为中国特色创新药物研发提供新策略和新模式。
Novel drug discovery from the active ingredients of traditional Chinese medicine is the most distinctive feature and advantageous field of China,which has provided an unprecedented opportunity.However,there are still problems such as unclear functional substance basis,action targets and mechanism,which greatly hinder the clinical transformation of active ingredients in traditional Chinese medicine.Based on the analysis of the current status and progress of innovative drug research and development in China,this paper aimed to explore the prospect and difficulties of the development of natural active ingredients from traditional Chinese medicine,and to explore the efficient discovery of trace active ingredients in traditional Chinese medicine,and obtain drug candidates with novel chemical structure,unique target/mechanism and independent intellectual property rights,in order to provide a new strategy and a new model for the development of natural medicine with Chinese characteristics.
作者
栾鑫
黄敏
柯博文
葛广波
张卫东
LUAN Xin;HUANG Min;KE Bo-wen;GE Guang-bo;ZHANG Wei-dong(Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Shanghai Institute of Meteria Medica,Chinese Academy of Science,Shanghai 201203,China;West China Hospital of Sichuan University,Chengdu 610041,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2023年第7期1705-1710,共6页
China Journal of Chinese Materia Medica
基金
国家中医药管理局多学科交叉中药新药研发创新团队项目(ZYYCXTD-D-202004)。
关键词
临床有效中药
中药活性成分
创新药物
作用靶标
effective traditional Chinese medicine
active components
innovative drug
therapeutic targets