源于临床有效中药活性成分的创新药物研发策略与挑战

Strategy and challenge of innovative drug research and development from clinically effective ingredients of traditional Chinese medicine

源于中药活性成分的新药创制是我国创新药物研发的特色和优势领域,但目前仍然存在药效物质基础不清、作用靶标和机制不明确等问题,极大阻碍了中药活性成分向新药物的临床转化。该文在分析整理当前我国创新药物研发现状及进展的基础上,针对中药活性成分发展前景及面临的困境,探讨实现中药活性成分高效发现,获得化学结构新颖、作用靶标/机制独特且具有自主知识产权的候选药物,以期为中国特色创新药物研发提供新策略和新模式。

Novel drug discovery from the active ingredients of traditional Chinese medicine is the most distinctive feature and advantageous field of China,which has provided an unprecedented opportunity.However,there are still problems such as unclear functional substance basis,action targets and mechanism,which greatly hinder the clinical transformation of active ingredients in traditional Chinese medicine.Based on the analysis of the current status and progress of innovative drug research and development in China,this paper aimed to explore the prospect and difficulties of the development of natural active ingredients from traditional Chinese medicine,and to explore the efficient discovery of trace active ingredients in traditional Chinese medicine,and obtain drug candidates with novel chemical structure,unique target/mechanism and independent intellectual property rights,in order to provide a new strategy and a new model for the development of natural medicine with Chinese characteristics.