以肿瘤治疗为例探讨中医药传统理论在现代中药纳米制剂中的应用

Application of traditional Chinese medicine theory in modern traditional Chinese medicine nano-preparation:taking tumor treatment as an example

中医药传统理论是以整体观为指导思想,以脏腑经络、气血津液为生理病理基础,以辨证论治为诊疗特点的医学理论,为人类健康维护和疾病防护做出了巨大贡献。现代中药制剂是在中医药理论的指导下,在继承和发展传统中药制剂的基础上,运用现代科学技术研制的制剂。目前,常见肿瘤的发病率与致死率逐年上升,中医用药治疗肿瘤具有丰富的临床经验。但现阶段,部分中药制剂有脱离中医药传统理论指导的趋势。随着中医药现代化的发展,中医药传统理论如何在现代中药制剂中发挥指导作用,是一个值商讨的问题。该文以肿瘤治疗为例介绍了在现代纳米技术的影响下中药纳米制剂的发展现状,并从中医药整体观、传统治则、引经理论三方面综述了中医药传统理论指导现代中药纳米制剂发展的现有研究,讨论了在中医药理论指导下中药纳米制剂整体治疗、药对搭配、载体选择以及靶向物质选择方面的应用前景。为中药纳米制剂的传统化和现代化进一步结合发展提供了新的参考。

With Zang-Fu organs,meridians,Qi and blood,and body fluid as the physiological and pathological basis,traditional Chinese medicine(TCM)theory is guided by the holistic concept and characterized by syndrome differentiation.It has made significant contributions to human health maintenance and disease prevention.Modern TCM preparation is developed on the basis of inheriting and developing TCM preparations using modern science and technology under the guidance of TCM theory.At present,the incidence and mortality of common tumors are increasing.TCM has rich clinical experience in the treatment of tumors.However,in the current stage,some TCM preparations have a tendency to deviate from the guidance of TCM theory.With the modernization of TCM,it is worth considering how TCM theory guides modern TCM preparations.Taking tumor treatment as an example,this paper introduced the development of TCM nano-preparation under the influence of modern nanotechnology,summarized the research on the development of modern TCM nano-preparation from the aspects of TCM holistic concept,TCM treatment principles,and TCM theory application,and discussed the application prospect of TCM nano-preparation in overall therapy,drug pairing,carrier selection,and targeted substance selection under the guidance of TCM theory.This paper provides new references for further developing the combination of tradition and modernization of TCM nano-preparation.