近十年中医药治疗阿尔茨海默病研究的可视化分析

Visual analysis of research on traditional Chinese medicine treatment of Alzheimer′s disease in recent ten years

该研究旨在应用文献计量学,探索近十年中医药治疗阿尔茨海默病(AD)的国内外研究现状、热点和趋势。计算机检索Web of science、中国知网(CNKI),搜索2012年1月1日至2022年8月15日中医药治疗AD的相关文献,利用CiteSpace 6.1R2和VOSviewer 1.6.15软件对作者、国家、机构、关键词、期刊等进行可视化分析。共纳入中文文献2254篇,英文文献545篇,年发文量总体呈波动上升趋势,发文量最多和中介中心性最大的国家均为中国,中、英文文献发文量最多的作者分别为孙国杰和WANG Qi,中、英文文献发文量最多的机构分别为湖北中医药大学和北京中医药大学,被引频次最高和中介中心性最高的英文期刊分别为《Journal of Ethnopharmacology》和《Neuroscience Letters》,中、英文文献的关键词分析显示中医药治疗AD研究主要集中在作用机制和治疗方法等方面,其中代谢组学、肠道菌群、氧化应激、tau蛋白过度磷酸化、β-淀粉样蛋白(Aβ)、炎症因子、自噬等为作用机制方面的研究重点,针刺、临床效果、肾虚痰瘀、通督启神等为临床研究方面的重点。该研究领域尚处于探索发展阶段,后续需加强各机构间有效的交流合作,开展更多中医药治疗AD的高质量基础研究,获得高级别循证医学证据,明确发病机制和方剂机制。

This study employed bibliometrics tools to review the studies of traditional Chinese medicine(TCM)treatment of Alzheimer′s disease(AD)in recent ten years,aiming to explore the research status,hotspots,and future trends in this field at home and abroad.The relevant literature published from January 1,2012 to August 15,2022 was retrieved from Web of Science and CNKI.CiteSpace 6.1R2 and VOSviewer 1.6.15 were used for the visual analysis of authors,countries,institutions,keywords,journals,etc.A total of 2254 Chinese articles and 545 English articles were included.The annual number of articles published showed a rising trend with fluctuations.The country with the largest number of relevant articles published and the largest centrality was China.SUN Guo-jie and WANG Qi were the authors publishing the most Chinese articles and English articles,respectively.Hubei University of Chinese Medicine and Beijing University of Chinese Medicine published the most articles in Chinese and English,respectively.Journal of Ethnopharmacology and Neuroscience Letters published the articles with the highest cited frequency and the highest centrality.According to the keywords,the research on TCM treatment of AD mainly focused on the mechanism of action and treatment methods.Metabolomics,intestinal flora,oxidative stress,tau hyperphosphorylation,β-amyloid(Aβ),inflammatory cytokines,and autophagy were the focuses of the research on mechanism of action.Acupuncture,clinical effect,kidney deficiency and phlegm stasis,and dredging governor vessel to revitalize mind were the hotspots of clinical research.This research field is still in the stage of exploration and development.Exchanges and cooperation among institutions should be encouraged to carry out more high-quality basic research on TCM treatment of AD,obtain high-level evidence,and clarify the pathogenesis and prescription mechanism.