青少年身体活动强度与心血管代谢风险相关性meta分析

Meta analysis of relationship between physical activity intensity and cardiovascularmetabolic risk in adolescents

目的 对身体活动强度与青少年心血管代谢风险之间的关系进行定量评估,以期为降低心血管代谢风险提供参考依据。方法 计算机检索pubmed、embase、the cochrane library、web of science、知网、万方、维普、sinomed各数据库从建库至2021年6月23日之前发表的相关文献,收集青少年身体活动与心血管代谢风险相关的研究,双人独立筛选文献、提取信息并依据美国卫生保健质量和研究机构(Agency for Healthcare-Research and Quality,AHRQ)推荐的标准评价文献质量,用review manager 5.3、stata 14.0进行meta分析。结果 共纳入8篇横断面研究,样本量为13 148例。Meta分析结果显示,与高强度身体活动青少年相比,低强度身体活动青少年的心血管代谢风险增高42%(OR=1.42,95%CI:1.25~1.61),中强度身体活动青少年的心血管代谢风险增高23%(OR=1.23,95%CI:1.07~1.41)。结论 与高强度身体活动相比,低强度和中强度身体活动是心血管代谢风险的危险因素,但随着青少年身体活动强度的增加,其心血管代谢风险明显呈降低的趋势。身体活动是可以改变的行为习惯,因此通过干预身体活动以降低心血管代谢风险具有重要的公共卫生意义。

Objective To quantitatively evaluate the relationship between physical activity intensity and cardiovascular metabolic risk in adolescents,so as to provide scientific basis for decrease of cardiovascular metabolic risk.Methods The pubmed,embase,the cochrane library,web of science,CNKI,WanFang,VIP and sinomed databases were searched by computer to retrieve the relevant literature from the establishment of the database to June 23,2021,to collect studies on the relationship between physical activity and cardiovascular metabolic risk in adolescents.Two evaluators independently selected articles and extracted information,and assessed literature quality according to the standard recommended by the Agency for Healthcare-Research and Quality(AHRQ).Review Manager 5.3 and Stata14.0 were used for meta analysis.Results A total of eight cross-sectional studies were included with a sample size of 13148 cases.Meta analysis showed that compared with adolescents with high-intensity physical activity,adolescents with low-intensity physical activity had an increased risk of cardiovascular metabolism by 42%(OR=1.42,95%CI:1.25-1.61),and adolescents with moderate-intensity physical activity had an increased risk of cardiovascular metabolism by 23%(OR=1.23,95%CI:1.07-1.41).Conclusions Compared with high-intensity physical activity,low-intensity and moderate-intensity physical activity are risk factors of cardiovascular metabolism,however,with the increase of physical activity intensity in adolescents,the risk of cardiovascular metabolism tends to decrease.The physical activity is a behavior habit that can be changed,so it has important public health significance to reduce the risk of cardiovascular metabolism by intervening the physical activity.