透明质酸钠对上皮下角膜磨镶术后角膜上皮愈合的影响

Sodium hyaluronate on the corneal epithelial healing after Laser subepithelial keratomileusis

目的 :研究促进准分子激光上皮下角膜磨镶术治疗近视后角膜上皮早期愈合的方法。方法 :LASEK治疗 2 5例 48眼近视。术后随机分成 2组 ,A组 3 2眼术后早期应用透明质酸钠滴眼剂 (0 1%爱丽 ) ,B组 16眼作为空白对照组。结果 :术后第一天A组较B组疼痛症状轻 (P <0 0 5 ) ,术后 3月两组角膜Haze、裸眼视力没有差别 (P >0 0 5 )。A组术后角膜接触镜粘附细胞较少 ,B组角膜接触镜粘附较多角膜上皮细胞。结论 :透明质酸钠滴眼剂可以促进LASEK后角膜上皮细胞愈合 ,明显减轻术后疼痛症状而对角膜Haze、术后视力没有影响。

Objective:To assess the effect of sodium hyaluronate on the corneal epithelial healing after Laser subepithelial keratomileusis. Methods:48 eyes of 25 patients underwent LASEK were divided into two groups.32 eyes in group A were treated with sodium hyaluronate eye drops(0.1% Hailid) postoperatively.16 eyes in group B as control. Results:The degree of pain in group A was lower than that in group B (P<0 05).There were no differences between the two groups in mean uncorrected visual and corneal haze at three months post operation (P>0 05).There were many corneal epithelial cells on contact lens in group B but few in group A. Conclusions:The sodium hyaluronate eyedrops could promote the healing of corneal epithelia and reduce postoperative pain but had no effect on the corneal haze or uncorrected visual acuity.