偏头痛与卵圆孔未闭的研究进展

Advances on the relationship between migraine and patent foramen ovale

偏头痛是临床常见的慢性致残性的神经系统疾病,超过半数的患者会因为偏头痛的发作而影响正常生活。近年来,大量研究表明偏头痛与卵圆孔未闭之间存在着一定的联系,但因为卵圆孔未闭发病率较高且引发偏头痛发作的病理机制不明,两者之间的因果关系尚存争议,经皮卵圆孔封堵术是否为治疗卵圆孔未闭合并偏头痛的有效治疗手段亦成为研究热点。该文将围绕卵圆孔未闭与偏头痛的相关性、两者间可能存在的发病机制以及封堵术治疗偏头痛的疗效展开综述。

Migraine is a clinically common,chronic and disabling neurological disorder,and more than half of sufferers have migraine attacks that interfere with their normal lives.In recent years,a large number of studies have shown that there is a certain association between migraine and patent foramen ovale(PFO),but the causal relationship between the two is still controversial due to the high incidence of PFO and the unknown pathophysiological mechanisms that triggers migraine attacks via PFO.Moreover,whether PFO closure is an effective treatment for migraine has become a hot topic.This review focuses on the correlation between PFO and migraine,the possible pathogenesis and the efficacy of PFO closure in the treatment of migraine.