美托洛尔联合依折麦布治疗老年冠心病的应用效果

The Application Effect of Metoprolol Combined with Ezetimibe in the Treatment of Elderly Coronary Heart Disease

目的分析探讨对老年冠心病患者使用美托洛尔联合依折麦布进行治疗的效果和价值。方法选择我院在2020年11月至2022年12月,收治的60例老年冠心病患者作为本次研究对象,按随机数字表法的方式将60例患者分为两组,每组各30例。对照组使用单一的依折麦布对老年冠心病患者进行治疗,研究组在对照组的基础上对老年冠心病患者联合使用美托洛尔进行治疗。从患者治疗后的心功能变化指标、血清学指标、血脂水平指标、肾素-血管紧张素-醛固酮系统(RAAS)功能评分、血管内皮功能评分以及患者的总不良反应率6个方面,比较两组治疗的效果。结果两组治疗结束后,研究组患者N末端脑利纳肽原、左心射血分数、左心室收缩末期内径、左心室舒张末期内径的变化指标优于对照组(P<0.05);研究组患者的白细胞介素-6、肿瘤坏死因子-α、C反应蛋白的水平指标低于对照组(P<0.05);研究组患者的低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、总胆固醇、三酰甘油的水平指标优于对照组(P<0.05);研究组患者的血浆肾素、血管紧张素Ⅱ以及肾上腺脑白质变性的水平指标低于对照组(P<0.05);研究组患者的血管内皮生长因子、内皮缩血管肽1、中性粒细胞计数的水平指标优于对照组(P<0.05);研究组患者出现低血压、高钾血症、肾功能损伤的人数少于对照组,差异均具有统计学意义(P<0.05)。结论在老年冠心病的治疗中联合使用美托洛尔和依折麦布,能降低患者出现不良反应的概率,改善患者的心功能情况以及血清、血脂指标等情况。

Objective To analyze and explore the efficacy and value of using metoprolol and ezetimibe in the treatment of elderly patients with coronary heart disease.Methods Sixty elderly patients with coronary heart disease admitted to our hospital from November 2020 to December 2022 were selected as the study subjects.The 60 patients were divided into two groups using a random number table method,with 30 patients in each group.The control group treated elderly patients with coronary heart disease with a single ezetimibe,while the study group treated elderly patients with coronary heart disease with metoprolol in combination on the basis of the control group.Compare the therapeutic effects of the two groups from six aspects:changes in cardiac function,serological indicators,blood lipid levels,renin angiotensin aldosterone system(RAAS)function score,vascular endothelial function score,and total adverse reaction rate of patients after treatment.Results After the completion of treatment in both groups,the changes in N-terminal pro-brain natriuretic peptide,left ventricular ejection fraction,left ventricular end systolic diameter,and left ventricular end diastolic diameter in the study group were better than those in the control group(P<0.05).Interleukin-6 and tumor necrosis factor in the study group of patients-α,the level indicators of C-reactive protein were better than those of the control group(P<0.05).The levels of lowdensity lipoprotein cholesterol,high-density lipoprotein cholesterol,total cholesterol and triacylglycerol in the study group were better than those in the control group(P<0.05).The levels of plasma renin,angiotensin II,and adrenoleukodystrophy in the study group were better than those in the control group(P<0.05).The levels of vascular endothelial growth factor,endothelial vasoconstrictor peptide 1,and neutrophil count in the study group were better than those in the control group(P<0.05).The number of patients in the study group experiencing hypotension,hyperkalemia,and renal function damage was lower than that in the control group,and the differences were statistically significant(P<0.05).Conclusion The combination of metoprolol and ezetimibe in the treatment of elderly coronary heart disease can reduce the probability of adverse reactions in patients,improve their cardiac function,serum and lipid indicators,and other conditions.