具有肾脏意义的单克隆免疫球蛋白病诊治进展

Advances in diagnosis and treatment of monoclonal gammopathy of renal significance

与意义不明的单克隆免疫球蛋白病(MGUS)不同,具有肾脏意义的单克隆免疫球蛋白病(MGRS)产生的肾毒性单克隆蛋白,可造成肾脏等脏器的不可逆性损伤,即使在肾移植术后也具有较高复发率。因此早期识别MGRS并开展靶向恶性增殖灶(B细胞/浆细胞性)的疗法,对于挽救脏器功能,改善预后具有重要意义。

Monoclonal gammopathy of renal significance(MGRS)is different from monoclonal gammopathy of undetermined significance(MGUS).Nephrotoxic monoclonal immunoglobulins produced by MGRS cause irreversible damage to human organs,especially kidneys.There is a high recurrence rate in MGRS patients after renal transplantation.Therefore,early identification of MGRS and treatments targeting malignant proliferative foci(B cell/plasma cell)are of great significance for saving organ function and improving prognosis.