菌群异常在帕金森病病情进展及治疗中的研究

Study of abnormal microflora in progression and treatment of Parkinson5s disease

帕金森病是老年人第二大常见的神经退行性疾病,最新研究为帕金森病肠道起源假说提供了证据,肠道菌群可通过肠道和大脑间的双向通信影响中枢神经系统。菌群异常通过引起α-突触核蛋白异常聚集在帕金森病中发挥重要作用,帕金森药物与肠道菌群可相互影响,特异菌群与帕金森病临床特征相关,改善肠道菌群组成可降低帕金森病发病风险,延缓疾病进程。该文对帕金森病菌群异常的病理生理、临床特征及治疗方面进行了综述。

Parkinson's disease is the second most common neurodegenerative disease in the elderly population.Recent research provides evidence for the hypothesis of the intestinal origin of Parkinson's disease.Intestinal flora can affect the central nervous system through two-way communication between the gut and brain.Abnormal microflora plays an important role in Parkinson's disease by causing abnonnal aggregation of a-synuclein.Parkinson5 s disease drugs can interact with intestinal microilora,and specific microflora is related to clinical characteristics of Parkinson*s disease.Improving the composition of intestinal microflora can reduce the risk of Parkinson's disease and delay the disease progression.In this article,the pathophysiology,clinical features and treatment of abnormal microflora in Parkinson's disease were reviewed.